Berson, D. M., Dunn, F. A. & Takao, M.
Phototransduction by retinal ganglion cells that set the circadian clock. Science
295, 1070–1073 (2002)
Melanopsin and rod–cone photoreceptive systems account for all major accessory visual functions in mice. Nature
424, 75–81 (2003)
Melanopsin is required for non-image-forming photic responses in blind mice. Science
301, 525–527 (2003)
Sekaran, S., Foster, R. G., Lucas, R. J. & Hankins, M. W.
Calcium imaging reveals a network of intrinsically light-sensitive inner-retinal neurons. Curr. Biol.
13, 1290–1298 (2003)
Warren, E. J., Allen, C. N., Brown, R. L. & Robinson, D. W.
Intrinsic light responses of retinal ganglion cells projecting to the circadian system. Eur. J. Neurosci.
17, 1727–1735 (2003)
Lucas, R., Douglas, R. & Foster, R.
Characterization of an ocular photopigment capable of driving pupillary constriction in mice. Nature Neurosci.
4, 621–626 (2001)
Lucas, R. J.
Identifying the photoreceptive inputs to the mammalian circadian system using transgenic and retinally degenerate mice. Behav. Brain Res.
125, 97–102 (2001)
Czeisler, C. A.
Suppression of melatonin secretion in some blind patients by exposure to bright light. N. Engl. J. Med.
332, 6–11 (1995)
Mrosovsky, N., Lucas, R. & Foster, R.
Persistence of masking responses to light in mice lacking rods and cones. J. Biol. Rhythms
16, 585–587 (2001)
Lockley, S. W.
Relationship between melatonin rhythms and visual loss in the blind. J. Clin. Endocrinol. Metab.
82, 3763–3770 (1997)
Hattar, S., Liao, H. W., Takao, M., Berson, D. M. & Yau, K. W.
Melanopsin-containing retinal ganglion cells: architecture, projections, and intrinsic photosensitivity. Science
295, 1065–1070 (2002)
Gooley, J. J., Lu, J., Chou, T. C., Scammell, T. E. & Saper, C. B.
Melanopsin in cells of origin of the retinohypothalamic tract. Nature Neurosci.
4, 1165 (2001)
Hannibal, J., Hindersson, P., Knudsen, S. M., Georg, B. & Fahrenkrug, J.
The photopigment melanopsin is exclusively present in pituitary adenylate cyclase-activating polypeptide-containing retinal ganglion cells of the retinohypothalamic tract. J. Neurosci.
22, RC191 (2002)
Lucas, R. J.
Diminished pupillary light reflex at high irradiances in melanopsin-knockout mice. Science
299, 245–247 (2003)
Provencio, I., Jiang, G., De Grip, W. J., Hayes, W. P. & Rollag, M. D.
Melanopsin: An opsin in melanophores, brain, and eye. Proc. Natl Acad. Sci. USA
95, 340–345 (1998)
Hubbard, R. & St. George, R.
The rhodopsin system of the squid. J. Gen. Physiol.
41, 501–528 (1958)
Liu, R. S., Crescitelli, F., Denny, M., Matsumoto, H. & Asato, A. E.
Photosensitivity of 10-substituted visual pigment analogues: detection of a specific secondary opsin-retinal interaction. Biochemistry
25, 7026–7030 (1986)
Hao, W. & Fong, H.
The endogenous chromophore of retinal G protein-coupled receptor opsin from the pigment epithelium. J. Biol. Chem.
274, 6085–6090 (1999)
Bistable UV pigment in the lamprey pineal. Proc. Natl Acad. Sci. USA
101, 6687–6691 (2004)
Action spectrum for melatonin regulation in humans: evidence for a novel circadian photoreceptor. J. Neurosci.
21, 6405–6412 (2001)
Thapan, K., Arendt, J. & Skene, D.
An action spectrum for melatonin suppression: evidence for a novel non-rod, non-cone photoreceptor system in humans. J. Physiol. (Lond.)
535, 261–267 (2001)
Hankins, M. W. & Lucas, R. J.
The primary visual pathway in humans is regulated according to long-term light exposure through the action of a nonclassical photopigment. Curr. Biol.
12, 191–198 (2002)
Newman, L. A., Walker, M. T., Brown, R. L., Cronin, T. W. & Robinson, P. R.
Melanopsin forms a functional short-wavelength photopigment. Biochemistry
42, 12734–12738 (2003)
A novel human opsin in the inner retina. J. Neurosci.
20, 600–605 (2000)
Bellingham, J., Whitmore, D., Philp, A. R., Wells, D. J. & Foster, R. G.
Zebrafish melanopsin: isolation, tissue localisation and phylogenetic position. Brain Res. Mol. Brain Res.
107, 128–136 (2002)
Inhibition of receptor/G protein coupling by suramin analogues. Mol. Pharmacol.
50, 415–423 (1996)
G proteins and dual control of adenylate cyclase. Cell
36, 577–579 (1984)
Asano, T. & Ogasawara, N.
Uncoupling of gamma-aminobutyric acid B receptors from GTP-binding proteins by N-ethylmaleimide: effect of N-ethylmaleimide on purified GTP-binding proteins. Mol. Pharmacol.
29, 244–249 (1986)
Zemelman, B. V., Lee, G. A., Ng, M. & Miesenbock, G.
Selective photostimulation of genetically chARGed neurons. Neuron
33, 15–22 (2002)
Leszkiewicz, D., Kandler, K. & Aizenman, E.
Enhancement of NMDA receptor-mediated currents by light in rat neurones in vitro
. J. Physiol. (Lond.)
524, 365–374 (2000)
Induction of photosensitivity by heterologous expression of melanopsin. Nature doi:10.1038/nature03345 (this issue)
Illumination of the melanopsin signaling pathway. Science
307, 600–604 (2005)