Abstract
(Arising from: Y. Okazaki et al. Nature 420, 563–573 200210.1038/nature01266; Okazaki et al. reply)
Okazaki et al. have argued that as many as 15,815 of 33,409 non-redundant mouse complementary DNAs may represent functional RNA genes1, on the basis of their findings that some of these cDNAs are confirmed by expressed sequence tagging and are found near CpG islands or polyadenylation signals2 — although many are expressed at such low levels that they could not be detected by microarray analysis3. We show here that conservation of these ‘non-coding’ cDNAs in rats or humans is no better than in an evolutionarily neutral control. Our results indicate that they are either non-functional or, if they are functional, are specific to a given species.
Your institute does not have access to this article
Relevant articles
Open Access articles citing this article.
-
Leveraging omic features with F3UTER enables identification of unannotated 3’UTRs for synaptic genes
Nature Communications Open Access 27 April 2022
-
Genome-wide detection and sequence conservation analysis of long non-coding RNA during hair follicle cycle of yak
BMC Genomics Open Access 01 October 2020
-
Impact of sequencing depth and technology on de novo RNA-Seq assembly
BMC Genomics Open Access 23 July 2019
Access options
Subscribe to Journal
Get full journal access for 1 year
$199.00
only $3.90 per issue
All prices are NET prices.
VAT will be added later in the checkout.
Tax calculation will be finalised during checkout.
Buy article
Get time limited or full article access on ReadCube.
$32.00
All prices are NET prices.
References
Okazaki, Y. et al. Nature 420, 563–573 (2002).
Numata, K. et al. Genome Res. 13, 1301–1306 (2003).
Bono, H. et al. Genome Res. 13, 1318–1323 (2003).
Griffiths-Jones, S., Bateman, A., Marshall, M., Khanna, A. & Eddy, S. R. Nucleic Acids Res. 31, 439–441 (2003).
Szymanski, M., Erdmann, V. A. & Barciszewski, J. Nucleic Acids Res. 31, 429–431 (2003).
Waterston, R. H. et al. Nature 420, 520–562 (2002).
Schwartz, S. et al. Genome Res. 13, 103–107 (2003).
Eddy, S. R. Cell 109, 137–140 (2002).
Lim, L. P., Glasner, M. E., Yekta, S., Burge, C. B. & Bartel, D. P. Science 299, 1540 (2003).
Nesterova, T. B. et al. Genome Res. 11, 833–849 (2001).
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Wang, J., Zhang, J., Zheng, H. et al. Neutral evolution of ‘non-coding’ complementary DNAs. Nature 431, 1–2 (2004). https://doi.org/10.1038/nature03016
Published:
Issue Date:
DOI: https://doi.org/10.1038/nature03016
Further reading
-
Leveraging omic features with F3UTER enables identification of unannotated 3’UTRs for synaptic genes
Nature Communications (2022)
-
Genome-wide detection and sequence conservation analysis of long non-coding RNA during hair follicle cycle of yak
BMC Genomics (2020)
-
Impact of sequencing depth and technology on de novo RNA-Seq assembly
BMC Genomics (2019)
-
Identification and characterization of the lncRNA signature associated with overall survival in patients with neuroblastoma
Scientific Reports (2019)
-
Long non-coding RNA in stem cell pluripotency and lineage commitment: functions and evolutionary conservation
Cellular and Molecular Life Sciences (2019)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
