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Mitochondrial permeability

Dual role for the ADP/ATP translocator?

Nature volume 430, page 984 (26 August 2004) | Download Citation

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Abstract

Arising from: J. E. Kokoszka et al. Nature 427, 461–464 (2004)  The ADP/ATP translocator (or adenine nucleotide translocase; ANT) is thought to play a dual role: in the transport of ADP and ATP across the mitochondrial inner membrane and in the formation of the mitochondrial permeability-transition pore (mtPTP), a nonspecific pore that is an important mediator of apoptosis (programmed cell death)1,2,3. However, Kokoszka et al.4 have shown that mitochondria from livers of ‘ANT-knockout’ mice, in which the ANT has been genetically inactivated, still possess mtPTP activity. From this, the authors conclude that the ANT is a non-essential component of the mtPTP that may be dispensable for mtPTP-associated cell death4. These results, which contradict previous evidence1,2 and cast doubt on a widely accepted model for the mtPTP (ref. 1), warrant scrutiny and call for a fundamental reappraisal of the role of the ANT in liver metabolism.

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  1. Department of Biochemistry, University of Bristol, Bristol BS8 1TD, UK

    • Andrew P. Halestrap

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Correspondence to Andrew P. Halestrap.

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https://doi.org/10.1038/nature02816

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