Does gut hormone PYY3–36 decrease food intake in rodents?

  • A Corrigendum to this article was published on 22 September 2004


Arising from: R. L. Batterham et al. Nature 418, 650–654 (2002); Batterham et al. reply

Batterham et al. report that the gut peptide hormone PYY3–36 decreases food intake and body-weight gain in rodents1, a discovery that has been heralded as potentially offering a new therapy for obesity. However, we have been unable to replicate their results. Although the reasons for this discrepancy remain undetermined, an effective anti-obesity drug ultimately must produce its effects across a range of situations. The fact that the findings of Batterham et al.1 cannot easily be replicated calls into question the potential value of an anti-obesity approach that is based on administration of PYY3–36.

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Figure 1: Lack of inhibitory effect of PYY3–36 on food intake in rodents.


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Correspondence to M. Tschöp.

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Competing interests

Several of the authors consult with, and have received financial support from, companies and institutions, including pharmaceutical firms, that may have active programmes relating to PYY3–36 of which we are not aware. Several of these companies have obesity-treatment development programmes and may therefore, from some perspectives, be considered competitors to companies pursuing PYY3–36.

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Tschöp, M., Castañeda, T., Joost, H. et al. Does gut hormone PYY3–36 decrease food intake in rodents?. Nature 430, 1–3 (2004).

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