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Stem cells

Lost in translation

The potential use of stem cells as agents of repair in human disease makes them the subject of high-profile studies. But we should be wary of prematurely pushing laboratory research into clinical practice.

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Figure 1: Two strategies used to show that bone-marrow stem cells do not take on the role of damaged heart cells.

MASA HOSHIJIMA

Figure 2: From experiment to therapy.

References

  1. Orlic, D. et al. Nature 410, 701–705 (2001).

    ADS  CAS  Article  Google Scholar 

  2. Murry, C. et al. Nature doi:10.1038/nature02446 (2004).

  3. Balsam, L. B. et al. Nature doi:10.1038/nature02460 (2004).

  4. Orlic, D. et al. Proc. Natl Acad. Sci. USA 98, 10344–10349 (2001).

    ADS  CAS  Article  Google Scholar 

  5. Cai, C. L. et al. Dev. Cell 5, 877–889 (2003).

    CAS  Article  Google Scholar 

  6. Alvarez-Dolado, M. et al. Nature 425, 968–973 (2003).

    ADS  CAS  Article  Google Scholar 

  7. Oh, H. et al. Proc. Natl Acad. Sci. USA 100, 12313–12318 (2003).

    ADS  CAS  Article  Google Scholar 

  8. Vassilopoulos, G., Wang, P. R. & Russell, D. W. Nature 422, 901–904 (2003).

    ADS  CAS  Article  Google Scholar 

  9. Wang, X. et al. Nature 422, 897–901 (2003).

    ADS  CAS  Article  Google Scholar 

  10. Dowell, J. D., Rubart, M., Pasumarthi, K. B., Soonpaa, M. H. & Field, L. J. Cardiovasc. Res. 58, 336–350 (2003).

    CAS  Article  Google Scholar 

  11. Bel, A. et al. Circulation 108, Suppl. 1, II247–II252 (2003).

    PubMed  Google Scholar 

  12. Kang, H. -J. et al. Lancet 363, 751–756 (2004).

    CAS  Article  Google Scholar 

  13. Menasche, P. Heart Fail. Rev. 8, 221–227 (2003).

    Article  Google Scholar 

  14. Chien, K. R. & Olson, E. N. Cell 110, 153–162 (2002).

    CAS  Article  Google Scholar 

Download references

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Chien, K. Lost in translation. Nature 428, 607–608 (2004). https://doi.org/10.1038/nature02500

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