Nature 412, 355–358 (2001).
In this Letter it was reported that an amino-terminal CDK-inhibitory domain of the Cdc6 replication protein was required for efficient mitotic exit, and that removal of this domain lethally blocked mitotic exit in cells lacking the Sic1 CDK inhibitor, demonstrating essential CDK-inhibitory control of CDK activity. However, Archambault et al.1 have shown that viable mitotic-exit-competent strains lacking both CDK-inhibitors can be constructed, a finding that has also been confirmed by the authors. Archambault et al.1 suggest that CDK-inhibitors are not required for mitotic exit in the wild-type cell cycle. However, A.C. et al. (manuscript in preparation) have evidence that strains lacking both CDK inhibitors may play a non-essential role in the regulation of mitotic exit. This point is still under investigation.
References
Archambault, V. et al. Genetic and biochemical evaluation of the importance of Cdc6 in regulating mitotic exit. Mol. Biol. Cell (in the press); advance online publication 5 September 2003 (doi:10.1091/mbc.E03-06-0384)
Additional information
The online version of the original article can be found at 10.1038/35085610
Rights and permissions
About this article
Cite this article
Calzada, A., Sacristán, M., Sánchez, E. et al. Correction: Corrigendum: Cdc6 cooperates with Sic1 and Hct1 to inactivate mitotic cyclin-dependent kinases. Nature 426, 584 (2003). https://doi.org/10.1038/nature02154
Issue Date:
DOI: https://doi.org/10.1038/nature02154
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
