Reproduction of many temperate zone birds is under photoperiodic control. The Japanese quail is an excellent model for studying the mechanism of photoperiodic time measurement because of its distinct and marked response to changing photoperiods. Studies on this animal have suggested that the mediobasal hypothalamus (MBH) is an important centre controlling photoperiodic time measurement1,2,3,4,5,6,7,8. Here we report that expression in the MBH of the gene encoding type 2 iodothyronine deiodinase (Dio2), which catalyses the intracellular deiodination of thyroxine (T4) prohormone to the active 3,5,3′-triiodothyronine (T3), is induced by light in Japanese quail. Intracerebroventricular administration of T3 mimics the photoperiodic response, whereas the Dio2 inhibitor iopanoic acid prevents gonadal growth. These findings demonstrate that light-induced Dio2 expression in the MBH may be involved in the photoperiodic response of gonads in Japanese quail.
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Sharp, P. J. & Follett, B. K. The effect of hypothalamic lesions on gonadotrophin release in Japanese quail (Coturnix coturnix japonica). Neuroendocrinology 5, 205–218 (1969)
Davies, D. T. & Follett, B. K. The neuroendocrine control of gonadotrophin release in Japanese quail. I. The role of the tuberal hypothalamus. Proc. R. Soc. Lond. B 191, 303–315 (1975)
Ohta, M. & Homma, K. Detection of neural connections to the infundibular complex by partial or complete hypothalamic deafferentation in male quail. Gen. Comp. Endocrinol. 68, 286–292 (1987)
Juss, T. S. in Avian Endocrinology (ed. Sharp, P. J.) 47–60 (Soc. Endocrinol., Bristol, 1993)
Konishi, H., Foster, R. G. & Follett, B. K. Evidence for a daily rhythmicity in the acute release of LH in response to electrical stimulation in the Japanese quail. J. Comp. Physiol. A 161, 315–319 (1987)
Ohta, M., Wada, M. & Homma, K. Induction of rapid testicular growth in quail by phasic electrical stimulation of the hypothalamic photosensitive area. J. Comp. Physiol. A 154, 583–589 (1984)
Meddle, S. L. & Follett, B. K. Photoperiodic activation of Fos-like immunoreactive protein in neurons within the tuberal hypothalamus of Japanese quail. J. Comp. Physiol. A 176, 79–89 (1995)
Meddle, S. L. & Follett, B. K. Photoperiodically driven changes in Fos expression within the basal tuberal hypothalamus and median eminence of Japanese quail. J. Neurosci. 17, 8909–8918 (1997)
Silver, R. et al. Coexpression of opsin- and VIP-like-immunoreactivity in CSF-contacting neurons of the avian brain. Cell Tissue Res. 253, 189–198 (1988)
Yasuo, S., Watanabe, M., Okabayashi, N., Ebihara, S. & Yoshimura, T. Circadian clock genes and photoperiodism: Comprehensive analysis of clock genes expression in the mediobasal hypothalamus, the suprachiasmatic nucleus and the pineal gland of Japanese quail under various light schedules. Endocrinology 144, 3742–3748 (2003)
Follett, B. K. & Sharp, P. J. Circadian rhythmicity in photoperiodically induced gonadotrophin release and gonadal growth in the quail. Nature 223, 968–971 (1969)
Kuenzel, W. J. & Masson, M. A Stereotaxic Atlas of the Brain of the Chick (Gallus domesticus) (Johns Hopkins Univ. Press, Baltimore, 1988)
Bernal, J. Action of thyroid hormone in brain. J. Endocrinol. Invest. 25, 268–288 (2002)
Prendergast, B. J., Mosinger, B. Jr, Kolattukudy, P. E. & Nelson, R. J. Hypothalamic gene expression in reproductively photoresponsive and photorefractory Siberian hamsters. Proc. Natl Acad. Sci. USA 99, 16291–16296 (2002)
Dawson, A., King, V. M., Bentley, G. E. & Ball, G. F. Photoperiodic control of seasonality in birds. J. Biol. Rhythms 16, 365–380 (2001)
Leonard, J. L. & Visser, T. J. in Thyroid Hormone Metabolism (ed. Hennemann, G.) 189–229 (Marcel Dekker, New York, 1986)
Follett, B. K. & Nicholls, T. J. Acute effect of thyroid hormones in mimicking photoperiodically induced release of gonadotropins in Japanese quail. J. Comp. Physiol. B 157, 837–843 (1988)
Follett, B. K., Nicholls, T. J. & Mayes, C. R. Thyroxine can mimic photoperiodically induced gonadal growth in Japanese quail. J. Comp. Physiol. B 157, 829–835 (1988)
Chopra, I. J. et al. Pathways of metabolism of thyroid hormones. Recent Prog. Horm. Res. 34, 521–567 (1978)
Follett, B. K. & Nicholls, T. J. Photorefractoriness in Japanese quail: possible involvement of the thyroid gland. J. Exp. Zool. 232, 573–580 (1984)
Follett, B. K. & Nicholls, T. J. Influences of thyroidectomy and thyroxine replacement on photoperiodically controlled reproduction in quail. J. Endocrinol. 107, 211–221 (1985)
Dawson, A. Thyroidectomy progressively renders the reproductive system of starlings (Sturnus vulgaris) unresponsive to changes in daylength. J. Endocrinol. 139, 51–55 (1993)
Dawson, A. thyroidectomy of house sparrow (Passer domesticus) prevents photo-induced testicular growth but not the increased hypothalamic gonadotrophin-releasing hormone. Gen. Comp. Endocrinol. 110, 196–200 (1998)
Dawson, A. & Thapliyal, J. P. Avian Endocrinology (eds Dawson, A. & Chaturvedi, C. M.) 141–151 (Narosa, New Delhi, 2001)
Nicholls, T. J., Follett, B. K., Goldsmith, A. R. & Pearson, H. Possible homologies between photorefractoriness in sheep and birds: the effect of thyroidectomy on the length of the ewe's breeding season. Reprod. Nutr. Dev. 28, 375–385 (1988)
Yoshimura, T. et al. Molecular analysis of avian circadian clock genes. Mol. Brain Res. 78, 207–215 (2000)
Tagawa, M. & Hirano, T. Presence of thyroxine in eggs and changes in its content during early development of chum salmon, Oncorhynchus keta. Gen. Comp. Endocrinol. 68, 129–135 (1987)
Ikuta, K., Aida, K., Okumoto, N. & Hanyu, I. Effects of sex steroids on the smoltification of masu salmon, Oncorhynchus masou. Gen. Comp. Endocrinol. 65, 99–110 (1987)
We thank Nagoya University Radioisotope Center for use of its facilities. We also thank K. Aida, M. Tagawa and A. Munakata for providing antiserum, and A. Nishimura for technical assistance. This work was supported by the Program for Promotion of Basic Research Activities for Innovative Biosciences (PROBRAIN), a Grant-in-Aid for Encouragement of Young Scientists (to T.Yo.), and a Grant-in-Aid for Scientific Research (to S.E.) from the Ministry of Education, Science, Sports and Culture.
The authors declare that they have no competing financial interests.
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Yoshimura, T., Yasuo, S., Watanabe, M. et al. Light-induced hormone conversion of T4 to T3 regulates photoperiodic response of gonads in birds. Nature 426, 178–181 (2003). https://doi.org/10.1038/nature02117
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