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The language of genes

Nature volume 420, pages 211–217 (2002)Cite this article

Abstract

Linguistic metaphors have been woven into the fabric of molecular biology since its inception. The determination of the human genome sequence has brought these metaphors to the forefront of the popular imagination, with the natural extension of the notion of DNA as language to that of the genome as the 'book of life'. But do these analogies go deeper and, if so, can the methods developed for analysing languages be applied to molecular biology? In fact, many techniques used in bioinformatics, even if developed independently, may be seen to be grounded in linguistics. Further interweaving of these fields will be instrumental in extending our understanding of the language of life.

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Figure 1: Grammar-style derivations of idealized versions of RNA structures.
Figure 2: Protein domain arrangements and the Chomsky hierarchy.
Figure 3: Distributions of the number of occurrences of Pfam protein domains (blue squares) in the genome of the yeast Saccharomyces cerevisiae, and of words (red diamonds) in Shakespeare's Romeo and Juliet, in both cases sorted in rank order from left to right.

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Acknowledgements

I thank P. Agarwal, A. Lupas, N. Odendahl and K. Rice for helpful comments on the manuscript.

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  1. Bioinformatics Division, Genetics Research, GlaxoSmithKline Pharmaceuticals, 709 Swedeland Road, PO Box 1539, King of Prussia, 19406, Pennsylvania, USA

    David B. Searls

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Searls, D. The language of genes. Nature 420, 211–217 (2002). https://doi.org/10.1038/nature01255

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