Cloning by nuclear transfer from adult somatic cells is a remarkable demonstration of developmental plasticity. When a nucleus is placed in oocyte cytoplasm, the changes in chromatin structure that govern differentiation can be reversed, and the nucleus can be made to control development to term.
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We each acknowledge discussions with colleagues during the development of these ideas and are grateful for funding from the governments, charities and commercial agencies acknowledged in our research papers.
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Wilmut, I., Beaujean, N., de Sousa, P. et al. Somatic cell nuclear transfer. Nature 419, 583–587 (2002). https://doi.org/10.1038/nature01079
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