Our editors' pick of this year’s most influential expert opinions.

Establish principles for rapid and responsible data sharing in epidemics, urge Nathan L. Yozwiak, Stephen F. Schaffner and Pardis C. Sabeti. 25 February 2015

Private finance can drive the energy transformation needed to meet global emissions goals — if backed by the right policies, says Nathan Fabian. 4 March 2015

Heritable human genetic modifications pose serious risks, and the therapeutic benefits are tenuous, warn Edward Lanphier, Fyodor Urnov and colleagues. 12 March 2015

David G. Victor calls for the IPCC process to be extended to include insights into controversial social and behavioural issues. 1 April 2015

Use these ten principles to guide research evaluation, urge Diana Hicks, Paul Wouters and colleagues. 22 April 2015

Address the needs of poor and rural households, target subsidies and support low-carbon industries, urge Arunabha Ghosh and Karthik Ganesan. 13 May 2015

The research community and the public require a fast, flexible response to the synthesis of morphine by engineered yeasts, urge Kenneth Oye, Tania Bubela and J. Chappell H. Lawson. 18 May 2015

ITER director-general Bernard Bigot explains how he will strengthen leadership and management to refocus the project's aim of harnessing nuclear fusion. 9 June 2015

Testing Ebola treatments in West Africa's epidemic happened too late. Research response during future outbreaks must be more nimble, says Trudie Lang. 5 August 2015

More fields should, like particle physics, adopt blind analysis to thwart bias, urge Robert MacCoun and Saul Perlmutter. 7 October 2015

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Comment pieces of 2015. Nature (2015). https://doi.org/10.1038/nature.2015.19010
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DOI: https://doi.org/10.1038/nature.2015.19010