Phosphorylation of the p70 S6 kinase 1 (S6K1) substrate ribosomal protein S6 at multiple sites is increased following extinction training relative to box controls. The extinction-induced increased S6 phosphorylation is blocked by the S6K1 inhibitor PF-4708671. Please refer to the article by Huynh et al. on pages 1394–1401.
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Huynh, T., Santini, E., Mojica, E. et al. Extinction of auditory threat memory triggers activation of p70 S6 kinase 1 in the basolateral nucleus of the amygdala. Mol Psychiatry 23, 1393 (2018). https://doi.org/10.1038/mp.2018.8