Figure 3

From: A paternal methyl donor-rich diet altered cognitive and neural functions in offspring mice

Figure 3

DNA methylation changes in hippocampal tissue of MD F1 mice. (a) Targeted bisulfite sequencing-based analysis of CpG methylation around the Kcnmb2 transcription start site in hippocampal tissue of MD F1 and CD F1 mice (n=4 mice per group). (b) Genome-wide DNA methylation analyses using MeDIP-chip identified processes and pathways enriched among genes linked to hypermethylated regions in MD mice (fathers, F1 offspring, F2 offspring; for full results of the Ingenuity pathway analyses, see Supplementary Data Files 3). CD, control diet; MD, methyl donor-rich diet.