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A brief proposal for improving clinical trials

Recent advances in diagnostics may significantly inspire and streamline clinical trials

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  1. Niculescu AB, Levey D, Le-Niculescu H, Niculescu E, Kurian SM, Salomon D . Psychiatric blood biomarkers: avoiding jumping to premature negative or positive conclusions. Mol Psychiatry 2015; 20: 286–288.

    CAS  Article  Google Scholar 

  2. Le-Niculescu H, Levey DF, Ayalew M, Palmer L, Gavrin LM, Jain N et al. Discovery and validation of blood biomarkers for suicidality. Mol Psychiatry 2013; 18: 1249–1264.

    CAS  Article  Google Scholar 

  3. Niculescu AB, Levey DF, Phalen PL, Le-Niculescu H, Dainton HD, Jain N et al. Understanding and predicting suicidality using a combined genomic and clinical risk assessment approach. Mol Psychiatry 2015; 20: 1266–1285.

    CAS  Article  Google Scholar 

  4. Niculescu AB, Lulow LL, Ogden CA, Le-Niculescu H, Salomon DR, Schork NJ et al. PhenoChipping of psychotic disorders: a novel approach for deconstructing and quantitating psychiatric phenotypes. Am J Med Genet B Neuropsychiatr Genet 2006; 141B: 653–662.

    Article  Google Scholar 

  5. Chen R, Mias GI, Li-Pook-Than J, Jiang L, Lam HY, Miriami E et al. Personal omics profiling reveals dynamic molecular and medical phenotypes. Cell 2012; 148: 1293–1307.

    CAS  Article  Google Scholar 

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Acknowledgements

This work was supported by an NIH Directors’ New Innovator Award (1DP2OD007363) and a VA Merit Award (2I01CX000139) to ABN. I would like to thank members of the Niculescu group for their excellent work over the years, and helpful discussions and comments, particularly, Helen Le-Niculescu, Daniel Levey and Peter Phalen.

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Correspondence to A B Niculescu.

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The author declares no conflict of interest related to this work. ABN is listed as inventor on a patent application being filed by Indiana University.

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Niculescu, A. A brief proposal for improving clinical trials. Mol Psychiatry 21, 736–737 (2016). https://doi.org/10.1038/mp.2016.42

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