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The role of SHANK2 rare variants in schizophrenia susceptibility

Molecular Psychiatry volume 20, page 1486 (2015)Cite this article

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In a recent paper, Peykov et al.1 tried to find evidence for the role of SHANK2 in schizophrenia (SCZ) susceptibility by sequencing and experimental analysis. The authors claim that ‘results strongly suggest a causative role of rare SHANK2 variants in SCZ’. Unfortunately, this conclusion is not well supported by their data.

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Acknowledgements

JC is supported by grants FIS/FEDER PI11/00770 and CP11/00163 from Instituto de Salud Carlos III. I thank the NHLBI GO Exome Sequencing Project and its ongoing studies that produced and provided exome variant calls for comparison: the Lung GO Sequencing Project (HL-102923), the WHI Sequencing Project (HL-102924), the Broad GO Sequencing Project (HL-102925), the Seattle GO Sequencing Project (HL-102926) and the Heart GO Sequencing Project (HL-103010).

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  1. Instituto de Investigación Sanitaria de Santiago, Hospital Clínico Universitario, SERGAS, Santiago de Compostela, Spain

    J Costas

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  1. J Costas
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Correspondence to J Costas.

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Costas, J. The role of SHANK2 rare variants in schizophrenia susceptibility. Mol Psychiatry 20, 1486 (2015). https://doi.org/10.1038/mp.2015.119

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