Table 2B ADHD risk associated with maternal antidepressant exposure during pregnancy

From: Prenatal antidepressant exposure is associated with risk for attention-deficit hyperactivity disorder but not autism spectrum disorder in a large health system

  ADHD Controls ADHD vs ADHD-matched Controls a
  2243 5631 Unadjusted Model 1 Model 2
Antidepressant exposure    OR (95% CI) OR (95% CI) OR (95% CI)
Time period
 Prepregnancy 4.1% 2.6% 1.60 (1.23–2.08)***   1.69 (1.25–2.25)***   1.18 (0.86–1.61)  
 Preconception (conception - 30 days) 1.3% 0.6% 2.37 (1.42–3.94)**   2.92 (1.68–5.11)***   2.15 (1.21–3.82)**  
 1st trimester 1.6% 0.6% 2.61 (1.62–4.21)***   2.79 (1.67–4.66)***   2.03 (1.19–3.44)**  
 2nd trimester 1.3% 0.8% 1.72 (1.07–2.73)*   1.51 (0.89–2.52)   0.98 (0.56–1.68)  
 3rd trimester 1.6% 0.8% 1.99 (1.28–3.07)**   2.02 (1.23–3.28)**   1.29 (0.76–2.15)  
 Pregnancy (preconception - delivery) 2.8% 1.2% 2.30 (1.62–3.24)***   2.53 (1.73–3.69)***   1.81 (1.22–2.70)**  
  1. Abbreviations: ADHD, attention-deficit hyperactivity disorder; ASD, Autism Spectrum Disorder; CI, confidence interval; OR, odds ratio.
  2. Unadjusted and adjusted risk of ADHD compared with ASD-matched controls; Significance at P<0.05 (*), <0.01 (**), <0.001 (***). Model 1 is adjusted for gender, race, birth year, insurance type, maternal age and median income tertile. Model 2 is adjusted for variables in model 1 and past history of maternal depression.