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Distinctively higher plasma G72 protein levels in patients with schizophrenia than in healthy individuals

Molecular Psychiatry volume 19, pages 636–637 (2014)Cite this article

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G72 protein regulates D-serine, a potent co-agonist of the N-methyl-D-aspartate (NMDA) neurotransmission, which is implicated in the pathophysiology of schizophrenia. This study found that the peripheral G72 protein expression is distinctively higher in patients with schizophrenia than in healthy individuals.

Evidence from the views of neurodevelopment, pathological finding, genetic vulnerability, animal models, pharmacology and clinical trials support that glutamatergic signaling, particularly the molecules of the NMDA synapse, has an important role in the pathophysiology of schizophrenia.1, 2 In clinical trials, NMDA-enhancing agents improved symptomatology in patients with schizophrenia.3

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References

  1. Harrison PJ, Weinberger DR . Mol Psychiatry 2005; 10: 40–68, (image 45).

    Article  CAS  Google Scholar 

  2. Lin CH, Lane HY, Tsai GE . Pharmacol Biochem Behav 2012; 100: 665–677.

    Article  CAS  PubMed  Google Scholar 

  3. Lane HY, Chang YC, Liu YC, Chiu CC, Tsai GE . Arch Gen Psychiatry 2005; 62: 1196–1204.

    Article  CAS  PubMed  Google Scholar 

  4. Wang X, He G, Gu N, Yang J, Tang J, Chen Q et al. Biochem Biophys Res Commun 2004; 319: 1281–1286.

    Article  CAS  PubMed  Google Scholar 

  5. Chumakov I, Blumenfeld M, Guerassimenko O, Cavarec L, Palicio M, Abderrahim H et al. Proc Natl Acad Sci USA 2002; 99: 13675–13680.

    Article  CAS  Google Scholar 

  6. Boks MP, Rietkerk T, van de Beek MH, Sommer IE, de Koning TJ, Kahn RS . Eur Neuropsychopharmacol 2007; 17: 567–572.

    Article  CAS  PubMed  Google Scholar 

  7. Hashimoto K, Fukushima T, Shimizu E, Komatsu N, Watanabe H, Shinoda N et al. Arch Gen Psychiatry 2003; 60: 572–576.

    Article  CAS  Google Scholar 

  8. Bendikov I, Nadri C, Amar S, Panizzutti R, De Miranda J, Wolosker H et al. Schizophr Res 2007; 90: 41–51.

    Article  PubMed  Google Scholar 

  9. Tsai GE, Lin PY . Curr Pharm Des 2010; 16: 522–537.

    Article  CAS  PubMed  Google Scholar 

  10. Korostishevsky M, Kaganovich M, Cholostoy A, Ashkenazi M, Ratner Y, Dahary D et al. Biol Psychiatry 2004; 56: 169–176.

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Institute of Clinical Medical Science, China Medical University, Taichung, Taiwan

    C-H Lin, H-T Chang & H-Y Lane

  2. Department of Psychiatry, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan

    C-H Lin

  3. Graduate Institute of Molecular Systems Biomedicine, Graduate Institute of Basic Medical Science & Ph.D. Program for Aging, China Medical University, Taichung, Taiwan

    H-T Chang

  4. Department of Medical Laboratory Science and Biotechnology, China Medical University, Taichung, Taiwan

    Y-J Chen

  5. Department of Adult Psychiatry, Kai-Suan Psychiatric Hospital, Kaohsiung, Taiwan

    C-H Lin

  6. Department of Psychiatry, China Medical University Hospital, Taichung, Taiwan

    C-H Huang & H-Y Lane

  7. Department of Psychiatry, Harbor-UCLA Medical Center, CA, Torrance, USA

    Rene Tun & G E Tsai

Authors
  1. C-H Lin
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  2. H-T Chang
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Correspondence to H-Y Lane.

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Lin, CH., Chang, HT., Chen, YJ. et al. Distinctively higher plasma G72 protein levels in patients with schizophrenia than in healthy individuals. Mol Psychiatry 19, 636–637 (2014). https://doi.org/10.1038/mp.2013.80

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