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Methylation of the promoter of brain-derived neurotrophic factor exon IV and antidepressant response in major depression

Molecular Psychiatry volume 19, pages 281–283 (2014)Cite this article

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Insufficient response to antidepressant pharmacotherapy with monoaminergic drugs is a major problem in the therapy of major depression (MD), occurring in up to two-thirds of depressed patients. To date, there is no biological marker reliably determining patients at high risk to treatment failure. Here, we report the first preliminary evidence that patients showing hypomethylation of the promoter region of the brain-derived neurotrophic factor (BDNF) gene are unlikely to benefit from antidepressant pharmacotherapy.

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Acknowledgements

This work was supported by in-house research funds of the University Medical Centre Mainz and Hannover Medical School. Parts of the doctoral thesis of Konrad F. Schlicht are incorporated into this report.

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Authors and Affiliations

  1. Department of Psychiatry and Psychotherapy, University Medical Centre, Mainz, Germany

    A Tadić, K F Schlicht, N Dreimüller & K Lieb

  2. Department of Psychiatry, Molecular Neuroscience Laboratory, Socialpsychiatry and Psychotherapy, Hannover Medical School (MHH), Hanover, Germany

    L Müller-Engling, A Kotsiari, A Kleimann, S Bleich & H Frieling

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  1. A Tadić
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  2. L Müller-Engling
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  3. K F Schlicht
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  7. S Bleich
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Correspondence to A Tadić.

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Competing interests

AT, KL, SB and HF are designated as inventors of the European patent number 12171541.1–2404 ‘Method for predicting response or non-response to a monoaminergic antidepressant’.

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Tadić, A., Müller-Engling, L., Schlicht, K. et al. Methylation of the promoter of brain-derived neurotrophic factor exon IV and antidepressant response in major depression. Mol Psychiatry 19, 281–283 (2014). https://doi.org/10.1038/mp.2013.58

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