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Functional SNPs are enriched for schizophrenia association signals

Molecular Psychiatry volume 19, pages 276–277 (2014)Cite this article

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Recent results suggest that there are likely to be many true association signals in large psychiatric genome-wide association study (GWAS) data sets.1 The big challenge of the field is the identification of these risk genes of small effect. We attempt to address this issue by using Psychiatric Genetics Consortium (PGC) GWAS data sets2, 3, 4 to test whether functional variants from the GWAS are significantly enriched in low P-values when compared with the remainder of the GWAS data set.

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Authors and Affiliations

  1. Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA

    S-A Bacanu, J Chen, K S Kendler & X Chen

  2. Departments of Biomedical Informatics and Psychiatry, Vanderbilt University School of Medicine, Nashville, TN, USA

    J Sun & Z Zhao

  3. Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Nutrition and Genomics Laboratory, Boston, MA, USA,

    K Richardson & C-Q Lai

  4. Department of Psychological Medicine, MRC Centre for Neuropsychiatric Genetics and Genomics, School of Medicine, Cardiff University, Cardiff, UK

    M C O'Donovan

Authors
  1. S-A Bacanu
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  2. J Chen
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  3. J Sun
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  4. K Richardson
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  5. C-Q Lai
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  6. Z Zhao
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  7. M C O'Donovan
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  8. K S Kendler
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  9. X Chen
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Corresponding author

Correspondence to X Chen.

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Supplementary Information accompanies the paper on the Molecular Psychiatry website

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Bacanu, SA., Chen, J., Sun, J. et al. Functional SNPs are enriched for schizophrenia association signals. Mol Psychiatry 19, 276–277 (2014). https://doi.org/10.1038/mp.2013.33

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