Table 1: Main meta-analysis: weighted mean ORs significantly >1 (highlighted in bold) indicate that the target allele was associated with obsessive–compulsive disorder

From: Molecular genetics of obsessive–compulsive disorder: a comprehensive meta-analysis of genetic association studies

GenePolymorphismTarget allele vs other allele(s)No. of data setsMean OR (and 99th percentile confidence interval)Obtained P-value for mean ORHolm- Bonferroni critical P-valueMean OR expressed as Cohen's dI2 (%)
5-HTTSTin2 VNTR12 vs non-12111.052 (0.845–1.309)0.5540.0060.02838
5-HTTLPRCoded as biallelicL vs S341.051 (0.937–1.179)0.2660.0050.02732
5-HTTLPRCoded as trialleicLa vs (Lg+S)81.251 (1.048–1.492)0.0010.0030.12321
BDNFrs6265Met vs Val121.013 (0.765–1.342)0.9040.0170.00756
COMTrs4680Met vs Val251.200 (1.001–1.438)0.0100.0030.10144
DAT1VNTR9 vs non-9 repeats81.260 (0.894–1.775)0.0820.0030.12724
DRD2rs1800497C vs T70.801 (0.535–1.198)0.1560.0040.12245
DRD3rs6280T vs C71.388 (0.901–2.139)0.0510.0030.18161
DRD4VNTR2 vs non-2 repeats100.837 (0.440–1.592)0.4760.0050.09860
DRD4VNTR4 vs non-4 repeats101.021 (0.639–1.631)0.9100.0250.01178
DRD4VNTR7 vs non-7 repeats101.041 (0.680–1.596)0.8070.0080.02258
HTR1Brs6296G vs C111.139 (0.860–1.509)0.2320.0040.07240
HTR2Ars6311 or rs6313A vs G (=T vs C)191.219 (1.037–1.433)0.0020.0030.10924
HTR2Crs6318Cys vs Ser60.956 (0.533–1.716)0.8430.0100.02550
MAOAEcoRVT vs C61.281 (0.516–3.182)0.4830.0070.13782
SLC1A1rs301430T vs C81.001 (0.771–1.301)0.9890.0500.00123
SLC1A1rs301434A vs G70.818 (0.492–1.359)0.3080.0040.11158
SLC1A1rs301979C vs G60.958 (0.548–1.675)0.8440.0130.02434
SLC1A1rs3087879G vs C51.600 (0.918–2.788)0.0290.0030.25945
SLC1A1rs3780412A vs G71.095 (0.633–1.810)0.6410.0060.05058
  1. Abbreviations: OR, odds ratio; VNTR, variable number tandem repeats.
  2. Significant results are also indicated by P-values for mean ORs that were larger than their corresponding Holm–Bonferroni P-values. The Holm–Bonferroni method is a sequential method of testing P-values (tested from smallest to largest) that maintains the family-wise error rate (that is, across the 20 ORs) at α=0.05.