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The impact of CACNA1C allelic variation on effective connectivity during emotional processing in bipolar disorder

Molecular Psychiatry volume 18, pages 526–527 (2013)Cite this article

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The A allele of the CACNA1C rs1006737 polymorphism is consistently associated with bipolar disorder (BD).1 No studies have examined the relationship between this polymorphism and brain connectivity, which is disrupted in BD.2 We investigated the relationship between rs1006737 polymorphism and effective connectivity in BD families. During perception of fearful faces, the presence of the A risk allele was associated with decreased outflow of information from medial frontal gyrus (MFG), which was significantly more marked in patients than in their unaffected relatives and healthy controls.

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References

  1. Sklar P, Smoller JW, Fan J, Ferreira MA, Perlis RH, Chambert K et al. Mol Psychiatry 2008; 13: 558–569.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Phillips ML, Ladouceur CD, Drevets C . Mol Psychiatry 2008; 13: 833–857.

    Article  Google Scholar 

  3. Surguladze SA, Marshall N, Schulze K, Hall MH, Walshe M, Bramon E et al. Neuroimage 2010; 53: 58–64.

    Article  CAS  PubMed  Google Scholar 

  4. Roth RB . www.ncbi.nlm.nih.gov/projects/geo/query/acc.cgi?acc=GSE3526.

  5. Sato JR, Fujita A, Cardoso EF, Thomaz CE, Brammer MJ, Amaro Jr E et al. Neuroimage 2010; 52: 1444–1455.

    Article  PubMed  Google Scholar 

  6. Surguladze SA et al. Transl Psychiatry 2012; 2: e70.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Strakowski SM, Delbello MP, Adler CM . Mol Psychiatry 2004; 10: 105–116.

    Article  Google Scholar 

  8. Jogia J, Ruberto G, Lelli-Chiesa G, Vassos E, Maierú M, Tatarelli R et al. Mol Psychiatry 2011; 16: 1070–1071.

    Article  CAS  PubMed  Google Scholar 

  9. Perrier E, Pompei F, Ruberto G, Vassos E, Collier D, Frangou S et al. Eur Psychiatry 2011; 26: 135–137.

    Article  CAS  PubMed  Google Scholar 

  10. Sklar P, Ripke S, Scott LJ, Andreassen OA, Cichon S, Craddock N et al. Nat Genet 2011; 43: 977–983.

    Article  CAS  PubMed Central  Google Scholar 

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Authors and Affiliations

  1. Institute of Psychiatry, King's College London, London, UK

    J Radua, S A Surguladze, N Marshall, M Walshe, E Bramon, D A Collier, D P Prata & R M Murray

  2. FIDMAG, CIBERSAM, Sant Boi de Llobregat, Barcelona, Spain

    J Radua

  3. Social and Affective Neuroscience Lab, Ilia State University, Tbilisi, Georgia

    S A Surguladze

  4. Department of Psychiatry, Clinical Science Institute, National University of Ireland, Galway, Galway, Ireland

    C McDonald

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  1. J Radua
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  2. S A Surguladze
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  3. N Marshall
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  4. M Walshe
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  5. E Bramon
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  6. D A Collier
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  7. D P Prata
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  8. R M Murray
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  9. C McDonald
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Correspondence to J Radua.

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Radua, J., Surguladze, S., Marshall, N. et al. The impact of CACNA1C allelic variation on effective connectivity during emotional processing in bipolar disorder. Mol Psychiatry 18, 526–527 (2013). https://doi.org/10.1038/mp.2012.61

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