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The impact of CACNA1C allelic variation on effective connectivity during emotional processing in bipolar disorder

Molecular Psychiatry volume 18, pages 526–527 (2013)Cite this article

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The A allele of the CACNA1C rs1006737 polymorphism is consistently associated with bipolar disorder (BD).1 No studies have examined the relationship between this polymorphism and brain connectivity, which is disrupted in BD.2 We investigated the relationship between rs1006737 polymorphism and effective connectivity in BD families. During perception of fearful faces, the presence of the A risk allele was associated with decreased outflow of information from medial frontal gyrus (MFG), which was significantly more marked in patients than in their unaffected relatives and healthy controls.

Participants in the study consisted of 20 remitted outpatients with BD1 (42±12years, 10 females, intelligence quotient (IQ)=114±15), 20 of their unaffected first-degree relatives (42±11years, 11 females, IQ=120±6) and 20 unrelated healthy controls (43±14years, 8 females, IQ=113±14), who had previously participated in an event-related functional magnetic resonance imaging study on emotional face processing.3

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Authors and Affiliations

  1. Institute of Psychiatry, King's College London, London, UK

    J Radua, S A Surguladze, N Marshall, M Walshe, E Bramon, D A Collier, D P Prata & R M Murray

  2. FIDMAG, CIBERSAM, Sant Boi de Llobregat, Barcelona, Spain

    J Radua

  3. Social and Affective Neuroscience Lab, Ilia State University, Tbilisi, Georgia

    S A Surguladze

  4. Department of Psychiatry, Clinical Science Institute, National University of Ireland, Galway, Galway, Ireland

    C McDonald

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  1. J Radua
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  2. S A Surguladze
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  3. N Marshall
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  4. M Walshe
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  5. E Bramon
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  6. D A Collier
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  8. R M Murray
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  9. C McDonald
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Correspondence to J Radua.

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Radua, J., Surguladze, S., Marshall, N. et al. The impact of CACNA1C allelic variation on effective connectivity during emotional processing in bipolar disorder. Mol Psychiatry 18, 526–527 (2013). https://doi.org/10.1038/mp.2012.61

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