Positive emotionality is associated with baseline metabolism in orbitofrontal cortex and in regions of the default network

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Abstract

Positive emotionality (PEM) (personality construct of well-being, achievement/motivation, social and closeness) has been associated with striatal dopamine D2 receptor availability in healthy controls. As striatal D2 receptors modulate activity in orbitofrontal cortex (OFC) and cingulate (brain regions that process natural and drug rewards), we hypothesized that these regions underlie PEM. To test this, we assessed the correlation between baseline brain glucose metabolism (measured with positron emission tomography and [18F]fluoro-deoxyglucose) and scores on PEM (obtained from the multidimensional personality questionnaire or MPQ) in healthy controls (n=47). Statistical parametric mapping (SPM) analyses revealed that PEM was positively correlated (Pc<0.05, voxel corrected) with metabolism in various cortical regions that included orbitofrontal (Brodman area, BA 11, 47) and cingulate (BA 23, 32) and other frontal (BA 10, 9), parietal (precuneus, BA 40) and temporal (BA 20, 21) regions that overlap with the brain's default mode network (DMN). Correlations with the other two main MPQ personality dimensions (negative emotionality and constraint) were not significant (SPM Pc<0.05). Our results corroborate an involvement of orbitofrontal and cingulate regions in PEM, which is considered a trait that protects against substance use disorders. As dysfunction of OFC and cingulate is a hallmark of addiction, these findings support a common neural basis underlying protective personality factors and brain dysfunction underlying substance use disorders. In addition, we also uncovered an association between PEM and baseline metabolism in regions from the DMN, which suggests that PEM may relate to global cortical processes that are active during resting conditions (introspection, mind wandering).

Introduction

The investigation of the neurobiological processes underlying personality characteristics may help understand the mechanisms by which personality can increase or decrease the risk for psychopathology.1 For substance abuse disorders (SUD), personality traits associated with greater vulnerability include impulsivity, novelty seeking and negative emotionality (NEM), whereas the personality trait of positive emotionality (PEM) is associated with resilience.2 Understanding the neurobiological mechanisms by which PEM may provide resilience against SUD would help develop strategies to emulate this for SUD prevention. However, the mechanisms by which PEM may protect against SUD are unclear, but are likely to reflect a common neurobiological substrate underlying this personality trait and its dysfunction in SUD.

Individuals with high scores on PEM have high reward sensitivity, are motivated and have a propensity to experience positive moods (that is, joy, enthusiasm). Dopamine, which is a neurotransmitter involved with reward and motivation, has been implicated in PEM.3, 4 Dopamine is also recognized to have a crucial role in the reinforcing effects of drugs and in the neuroadaptations that result in addiction (for review, see Volkow et al.5). Thus, dopaminergic pathways could underlie a common substrate for PEM and SUD. Indeed, brain imaging studies have documented an association between high striatal D2 receptor availability and high scores on PEM,6 and between high striatal D2 receptors and a greater resilience against the reinforcing effects of stimulant drugs in humans7, 8 and compulsive administration in rodents.9 In contrast, low striatal D2 receptor levels have been associated with a greater vulnerability to drug self-administration in laboratory animals10 and with SUD in humans (for review, see Volkow et al.5).

The involvement of dopamine in PEM is believed to be mediated in part via its regulation of prefrontal cortical regions, including orbitofrontal cortex (OFC) and anterior cingulate gyrus (ACC).3, 4 Indeed, as striatal D2 receptors are associated with metabolism in OFC and ACC (for review, see Volkow et al.5), we postulated that the association between PEM and striatal D2 receptors in healthy controls was mediated through the OFC and ACC. The OFC and ACC encode salience attribution of rewards,11, 12 including social13, 14 and drug rewards15 and the ACC is also involved in the representation of affective value.14 These regions are also crucial for inhibitory/impulse control and emotion regulation. Thus, differing activity of these regions could underlie differing sensitivity to rewards and differing emotional reactivity among individuals. Indeed, there is recent evidence linking gray matter density in the OFC and scores on the personality measure of social reward dependency.16

Here, we test the hypothesis that the OFC and ACC are involved in the personality trait of PEM. Specifically, we investigated whether baseline glucose metabolism, a marker of brain function,17 in the OFC and ACC was associated with PEM. Brain glucose metabolism was measured using positron emission tomography (PET) and [18F]fluoro-deoxyglucose (FDG) under baseline conditions (awake, eyes open, no stimulation) in healthy subjects (n=47). PEM was assessed using the multidimensional personality questionnaire (MPQ).18 We also assessed the correlations between brain glucose metabolism and the other two main personality dimensions from the MPQ (NEM and constraint) as a control against which to evaluate the specificity of any correlations found with PEM.

Materials and methods

Subjects

The 47 healthy controls reported in this study were participants in two separate protocols. One study recruited 23 healthy participants (study 1, unpublished data; 12 F, 30±9 years of age, two smokers) and the other included the baseline data from 24 healthy participants from a previously published study (study 2, 12 F, 33±7 years of age, five smokers).19 The demographic profiles of the subjects were similar for both studies. Subjects were recruited using public advertisement seeking healthy volunteers, who were initially screened by phone and subsequently evaluated for eligibility by a physician. Subjects were excluded if they had current or past psychiatric disorders (including drug abuse or dependence), neurological diseases, significant medical illnesses, were currently on medication(s) (including over-the-counter drugs) or were pregnant. As part of the evaluation procedure, subjects had a physical, psychiatric and neurologic examination. Routine laboratory tests were performed as well as a urine test to rule out the use of psychoactive drugs. Subjects were instructed to discontinue any over-the-counter medications 2 weeks prior to the PET scan and to refrain from drinking alcohol the week prior to the PET scan. Cigarettes, food and beverages (except for water) were discontinued at least 4 h prior to the study. The studies were approved by the local Institutional Review Board (Committee on Research Involving Human Subjects, Stony Brook University). After explaining the procedure, written informed consent was obtained from each subject.

Personality measures

Participants completed the MPQ.18 The personality measures were scored for the three main personality dimensions of the MPQ: PEM (or extraversion), NEM (or neuroticism) and constraint. The PEM includes measures of well-being, social potency, achievement (including motivation) and social closeness. The NEM includes measures of stress reactivity, alienation and aggression. The constraint factor includes measures of self-control, harm avoidance and traditionalism.

PET studies

PET studies were carried out with an HR+ tomograph (resolution 4.5 × 4.5 × 4.5 mm3 full-width half-maximum, 63 slices) in 3D dynamic acquisition mode. Subjects were scanned under baseline conditions with FDG as described.20 Briefly, a 20 min emission scan was started 35 min after injection of 4–6 mCi of FDG, and arterialized blood was used to measure FDG in plasma. During the uptake period of FDG, subjects were resting (no stimulation) in a quiet dimly lit room (eyes open) with a nurse by their side to ensure that they did not fall asleep. Thirty minutes after FDG injection, subjects were positioned in the PET scanner. Metabolic rates were computed using an extension of Sokoloff's model.21 The emission data for all the scans were corrected for attenuation and reconstructed using filtered back projection.

Image analysis and statistics

The data were analyzed both using statistical parametric mapping (SPM)22 and independently drawn regions of interest (ROI). The SPM analysis was performed on the images from all subjects (n=47) and the results were then subsequently corroborated for each of the two studies separately. For SPM analysis, the metabolic images were spatially normalized using the template provided in the SPM 99 package and subsequently smoothed with a 16 mm isotropic Gaussian kernel. Voxel-wise correlations were obtained between absolute glucose metabolism and the PEM scores (a priori set measure) and the scores in the NEM and constraint factors (to control for specificity in the correlations between regional metabolism and PEM). The threshold of significance was set to Pcorr<0.05, corrected for multiple comparisons with the random field theory.23 Clusters (>100 voxels) that were significant were overlaid on a magnetic resonance image of the human brain. For the analysis done on each separate study, we set the SPM threshold of significance to P<0.005, uncorrected cluster >100 voxels.

For ROI analysis, we extracted independently drawn ROIs using an automated extraction method that is based on the standard Talairach atlas.24 First, [18F]FDG images were mapped onto the Talairach brain using the SPM99 spatial normalization algorithm. The inverse mapping procedure was used to extract the Talairach coordinates of all voxels for a given anatomical region using the stereotaxtic coordinates in the Talairach Daemon database.25 These anatomically defined ROIs were overlapped voxel-by-voxel onto the SPM normalized PET image. These independently extracted ROIs were used to corroborate the significance (P<0.05) of the correlations between the personality measures and metabolism in the areas identified by SPM. Only findings that were significant both by SPM and by the independently extracted ROIs were considered significant.

Results

The scores of the personality measures did not differ between the subjects of the two separate studies. The average PEM scores were 49±11 (study 1: 52±13 and study 2: 47±9), the average NEM scores were 13±8 (study 1: 12±9 and study 2: 13±6) and the average constraint factor scores were 51±10 (study 1: 52±11 and study 2: 51±10).

The SPM analyses revealed a significant correlation between PEM and baseline metabolism in a broad range of cortical regions. To determine significance, we used a family-wise error threshold P<0.05, corrected for multiple comparisons at the voxel level (Figure 1). This identified eight clusters, all of which remained significant after the conservative family-wise error corrections for multiple comparisons (Table 1). These clusters were not only located in areas that included the left and right OFC and ACC but also identified additional areas in middle and lateral frontal (Brodman area, BA 9, 10), temporal gyrus (BA 20, 21, 22), parietal (precuneus, BA 7, 40) and in left and right occipital cortex (fusiform gyrus and superior occipital gyrus). Many of these regions are part of the default mode network (DMN), so to assess the degree of overlap we identified the location of the regions with positive correlations with PEM in a brain surface rendering where we projected the locations of the regions from the DMN and from the dorsal attention network as described by Buckner et al.26 (Figure 2). This identified significant overlap with DMN and minimal overlap with dorsal attention network.

Figure 1
figure1

Statistical parametric mapping (SPM) images identifying areas where metabolism was positively correlated with scores on positive emotionality (PEM). Significance corresponds to a family-wise error (FWE) threshold P<0.05, corrected for multiple comparisons at the voxel level. No regions showed a negative correlation.

PowerPoint slide

Table 1 SPM results showing the clusters where brain metabolism was significantly correlated with PEM, along with the regions where the clusters were centered (Gyrus and Brodman area (BA)), the Talairach stereotactic coordinate for center voxel (x, y, z), T-scores, the significance levels FDR corrected (PcCluster) and the more conservative family-wise error (FWE)-corrected (PcFWE) statistics
Figure 2
figure2

Statistical parametric mapping (SPM) identifying the areas where metabolism was significantly correlated with PEM as portrayed in a surface rendering of the brain where we projected the location of the regions from the default mode network or DMN (red) that is most active in passive task settings and of regions that are part of the dorsal attention network or DAN (blue) that focuses external attention and exhibits anticorrelated activity with the DMN.26 Abbreviations in the DMN refer to: to PCC (posterior cingulate), mPFC (medial prefrontal cortex), pIPL (posterior inferior parietal lobule), MTL (middle temporal lobule). Abbreviations in the DAN refer to: SPL (superior parietal lobule), IPS intraparietal sulcus (IPS), MT+ (motion-sensitive middle temporal area), FEF (frontal eye fields), dACC (dorsal anterior cingulated) and DLPFC (dorsolateral prefrontal cortex). Image is modified from Buckner et al. (2008).26

PowerPoint slide

Correlation analysis between PEM and the metabolic measures computed with independently extracted ROI corroborated significance for all the regions identified by SPM (Table 2; Figure 3). This analysis also revealed a significant positive correlation with whole brain metabolism (r=0.49, P<0.001).

Table 2 Correlation (‘r’) between PEM and regional brain metabolism computed using independent ROI analysis along with significance value (‘P’)
Figure 3
figure3

Regression slopes for the correlation between brain metabolism in orbitofrontal cortex (Brodman area, BA 11) and positive emotionality (PEM) (r=0.58, P<0.0001) and between metabolism in cingulate gyrus (BA 32) and PEM (r=0.53, P<0.0001). The regressions correspond to the averaged left and right regions.

PowerPoint slide

The SPM voxel-wise correlation analysis and the independent ROI analysis done separately for the subjects from study 1 and those from study 2 corroborated the findings from the analysis done in the complete study sample (Supplementary Figure 1; Supplementary Tables 1 and 2).

The SPM correlations with the NEM or the constraint factors were not significant (Pc<0.05). The threshold of significance had to be lowered to P<0.01 (uncorrected), to detect any associations. For NEM, SPM (P<0.01, uncorrected) revealed a negative correlation with metabolism in right thalamus and superior medial frontal gyrus (Supplementary Figure 2). The ROI analysis corroborated the negative correlation in right thalamus for middle dorsal (r=0.41, P<0.005) and ventral anterior nuclei (r=0.46, P<0.001), but not in superior medial frontal gyrus. For the constraint factor, SPM (P<0.01, uncorrected) revealed a positive correlation with metabolism in caudate (Supplementary Figure 3). The ROI analysis corroborated the positive correlation in left caudate (r=0.41, P<0.004) and a trend in right caudate (r=0.39, P<0.008).

Discussion

These findings corroborate our hypothesis of an involvement of the OFC and the ACC in the disposition to PEM. However, the positive correlations with PEM were not restricted to the OFC (BA 11, 47) and ACC (BA 23, 32), but encompassed a wide range of cortical regions that included other areas from middle and lateral frontal (BA 9, 10, 23), precuneus (BA 7, 31), parietal (BA 40), superior and middle temporal (BA 20, 21, 22) and fusiform cortices. Note that many of these cortical regions were located within the DMN (Figure 2).

The positive association between PEM and metabolic activity in medial and lateral OFC and in ACC in healthy controls is consistent with our findings in non-substance abusing subjects with a family history of alcoholism, in whom we also reported a positive correlation between PEM and baseline metabolic activity in OFC (BA 11, 25, 47) and ACC (BA 24, 32).6 These results are also in good agreement with those reported in healthy controls in whom the trait of social reward dependency, which relates to the PEM measure of social closeness, was associated with increased gray matter density in OFC (also basal ganglia and temporal lobes)16 and those in healthy women in whom extraversion, which relates to the PEM measure of social potency, was associated with OFC metabolism.27 Similarly, in healthy adults persistence, which relates to the PEM measure of achievement, was associated with OFC activation,28 and in adolescents higher effortful control, which also relates to achievement, was associated with larger OFC volume, whereas higher affiliativeness, which relates to the PEM measure of social closeness, was associated with larger ACC volume.29

The OFC and the ACC are involved in motivation and reward,30 social behaviors31 and emotional regulation,32 all of which are processes that contribute to the personality trait of PEM. Indeed, case studies have reported that damage to these brain regions in premorbidly normal patients resulted in personality changes that included amotivation and deviant social behaviors.33 Similarly, in humans, damage to the dorsal ACC is associated with apathetic behavior, lack of initiation and movement execution.34 In our findings, the areas in OFC (included BA 11, 47) and ACC (BA 24, 32) that correlated with PEM extended beyond the traditionally associated regions involved with reward and emotion regulation for OFC (BA 25, 11) and ACC (BA 24). However, there is evidence that BA 47 in the OFC participates in drug and monetary rewards35, 36 and that BA 32 in the dorsal ACC is involved in linking reward-related information with appropriate actions37, 38 and both BA 47 and BA 32 are implicated in addiction.36, 39

The investigation of the neurobiological processes underlying personality may help understand the mechanisms by which personality can serve as either a vulnerability factor or a protective factor in psychopathology.1 For SUD, the personality trait of PEM has been associated with protection against these disorders. Thus, we surmise, based on our results that increased activity in OFC and ACC could be linked with personality traits that offer a protection against SUD. Indeed, studies in substance abusers have consistently reported abnormal function of OFC and ACC.40, 41 Moreover, in subjects that despite a high genetic risk for alcoholism were not alcoholics, the higher than normal striatal D2R receptor availability was associated with OFC (BA 11, 25, 47) and CG (BA 24, 32) metabolism, which led us to postulate that these prefrontal regions may mediate resilience of these subjects to alcoholism.6

In contrast, certain personality traits of reward dependency, novelty seeking and impulsivity have been linked to a greater vulnerability for SUD.42 Imaging studies on the neurobiology of novelty seeking traits in healthy controls (n=31) reported a negative correlation with metabolism in precuneus and BA 7 and a positive correlation between reward dependency and caudate metabolism.43 The findings in precuneus and BA 7 showing a negative correlation with novelty seeking (trait that increases SUD risk), coupled with our findings showing of a positive correlation with PEM (personality dimension that is protective for SUD) implicates these regions as neurobiological substrates that may contribute to the vulnerability for SUD. A negative correlation between novelty seeking and metabolism in right middle temporal gyrus (as well as midbrain and parahippocampal gyrus) reported in a different study of healthy controls (n=16)44 also follows an opposite pattern to the positive correlation we report between PEM and metabolism in middle temporal gyrus (BA 21). The precuneus, superior parietal lobe and the middle temporal gyrus are not regions traditionally associated with rewards or SUD and, therefore, their potential role is unclear. On the other hand, these regions form part of the DMN that is associated with resting activity26 (Figure 2 shows the overlap with DMN), which alerts about the potential importance of a hypoactive DMN in the vulnerability for SUD. Alternatively, as discussed below increased activity of the DMN at rest may be a neurobiological substrate linked with the personality dimension of PEM.

The unexpected positive correlation between PEM and metabolism in a broad array of cortical regions was not observed for NEM or the constraint dimensions. As the metabolic measures were obtained at baseline (no stimulation), this raises the possibility that the personality trait of PEM may relate to global cortical processes that are active during resting conditions (that is introspection, mind wandering).26 Consistent with this interpretation is the pattern of correlations observed with the PEM that included regions implicated in the DMN (precuneus, BA 40, middle frontal cortex, middle temporal gyrus) and some more restricted overlap with regions implicated in the dorsal attention network (dorsal ACC, dorsolateral prefrontal cortex and superior parietal cortex) as well as visual regions.

This finding is also interesting in that PEM accounted for a significant portion of the overall intersubject variability in whole brain metabolism (r=0.49), the functional significance of which is not properly understood as it relates to healthy individuals. Our findings would suggest that baseline brain energetics may contribute to the personality trait of PEM. Considering that PEM is characterized by a higher propensity to engage in social interactions (social closeness and social potency) and in activities (achievement), studies that evaluate the relationship between brain glucose metabolism and sustainability of effort and engagement may help clarify the nature of this relationship.

In this report, we did not see an association on the SPM analysis (after voxel or cluster correction) between brain glucose metabolism and the NEM or the constraint factors of the MPQ unless we lowered the threshold of significance (P<0.01, uncorrected). The overall lack of an association between baseline brain metabolism and NEM and constraint factors could reflect the fact that we measured baseline brain activity (intrinsic activity), whereas imaging studies, which measure activation responses (evoked activity), may be better suited to assess these two dimensions of personality.

Another limitation of this study is that correlations do not connote causal associations and thus we cannot determine from our findings if the associations between resting cortical metabolism, including that in OFC and ACC, are causally linked with the personality trait of PEM.

In conclusion, we have related individual differences on personality measure of PEM to regional activity in a broad range of cortical regions that included the OFC and ACC. This corroborates our working hypothesis that activity in OFC and ACC would be associated with PEM. Inasmuch as dysfunction of the OFC and ACC are linked to SUD, these findings support a common neural basis for personality constructs that protect against SUD and their dysfunction in addiction. In addition, we uncovered an unpredicted association between PEM and baseline metabolism in a broad range of cortical regions (including regions of the DMN) that implicates the activity of resting networks in personality dimension of PEM.

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Acknowledgements

This research was supported by the National Institutes of Health (Intramural Research Program of the National Institute on Alcoholism and Alcohol Abuse and Grant AA 09481). We thank David Schlyer for cyclotron operations, Colleen Shea and Youwen Xu for radiotracer synthesis, Pauline Carter for nursing care, Karen Apelskog for protocol coordination and Ruben Baler and Linda Thomas for editorial assistance.

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Correspondence to N D Volkow.

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The authors declare no conflict of interest.

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Keywords

  • brain glucose metabolism
  • brain imaging
  • personality
  • prefrontal cortex
  • substance use disorder
  • vulnerability

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