Problems with mentalizing, also called Theory of Mind (ToM), are a hallmark of schizophrenia. Here we show that activation during mentalizing of emotions (green) in healthy controls is modulated by a genetic risk variant for psychosis. A frequent functional single-nucleotide polymorphism in an intron of the ZNF804A gene is the first genetic variant that has been found to be associated with schizophrenia and bipolar disorder on a genomewide significance level. Key areas of the ToM-Network (in red) previously found to be hypoactive in schizophrenia show decreasing ToM-specific activation with the number of risk alleles. For more info on this topic, please refer to the article by Walter et al. on pages 462–470.
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