Table 1 Publications implicating or not implicating each reviewed abnormality in ASD

From: A review of research trends in physiological abnormalities in autism spectrum disorders: immune dysregulation, inflammation, oxidative stress, mitochondrial dysfunction and environmental toxicant exposures

Abnormality Total publications identified Number (%) published in last 5 years Number (%) implicating abnormality in ASD Number (%) not implicating abnormality in ASD Clinical studies reporting an association/ no association Review or hypothesis reporting an association/ no association Animal models reporting an association/ no association Rett syndrome studies reporting an association/ no association Treatment studies reporting an association/ no association
Immune dysregulation or inflammation 437a 251/437 (57%) 416 (95%) 21 (5%) 231/21 111/0 34/0 19/0 21/0
Oxidative stress 115 84/115 (73%) 115 (100%) 0 (0%) 51/0 41/0 6/0 10/0 7/0
Mitochondrial dysfunction 153 80/153 (52%) 145 (95%) 8 (5%) 63/8 22/0 11/0 49/0 0/0
Environmental toxicant exposures 190b 137/190 (72%) 170 (89%) 20 (11%) 71/19 67/1 26/0 0/0 6/0
Total 895 552/895 (62%) 846 (95%) 49 (5%) 416/48 241/1 77/0 78/0 34/0
  1. Abbreviation: ASD, autism spectrum disorder.
  2. aExcluding 95 publications concerning a possible association between vaccines and immune dysregulation in ASD.
  3. bExcluding 47 publications concerning a possible association between thimerosal and ASD.