Inhalation of fine particulates alters hippocampal neuronal morphology

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Mice exposed for a long term to fine particulate matter have reduced spine density in the CA1 region of the hippocampus as compared with mice exposed to filtered air. These changes in hippocampal morphology are associated with impairments in learning and memory and increased depressive-like responses. Here, we show a (a) bright field image of the hippocampus ( × 25) and (b) a representative pyramidal neuron from the CA1 region ( × 400). Mice exposed to particulate matter showed (c) reduced spine density on CA1 apical dendrites ( × 1000). For more information on this topic, please refer to the article by Fonken et al. on pages 987–995.

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