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Inhalation of fine particulates alters hippocampal neuronal morphology

Molecular Psychiatry volume 16, page 973 (2011)Cite this article

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Mice exposed for a long term to fine particulate matter have reduced spine density in the CA1 region of the hippocampus as compared with mice exposed to filtered air. These changes in hippocampal morphology are associated with impairments in learning and memory and increased depressive-like responses. Here, we show a (a) bright field image of the hippocampus ( × 25) and (b) a representative pyramidal neuron from the CA1 region ( × 400). Mice exposed to particulate matter showed (c) reduced spine density on CA1 apical dendrites ( × 1000). For more information on this topic, please refer to the article by Fonken et al. on pages 987–995.

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Authors and Affiliations

  1. Departments of Neuroscience and Psychology, Ohio State University, Columbus, OH, USA

    L K Fonken, Z M Weil & R J Nelson

  2. Institute for Behavioral Medicine Research, Ohio State University, Columbus, OH, USA

    L K Fonken, Z M Weil & R J Nelson

  3. Division of Environmental Health Sciences, Ohio State University, Columbus, OH, USA

    X Xu & Q Sun

  4. Davis Heart and Lung Research Institute, Ohio State University, Columbus, OH, USA

    G Chen, Q Sun & S Rajagopalan

Authors
  1. L K Fonken
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  2. X Xu
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  3. Z M Weil
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  4. G Chen
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  5. Q Sun
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  6. S Rajagopalan
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  7. R J Nelson
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Fonken, L., Xu, X., Weil, Z. et al. Inhalation of fine particulates alters hippocampal neuronal morphology. Mol Psychiatry 16, 973 (2011). https://doi.org/10.1038/mp.2011.112

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  • DOI: https://doi.org/10.1038/mp.2011.112

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