Table 1: Summary of findings in PANDAS passive transfer mouse model

From: Passive transfer of streptococcus-induced antibodies reproduces behavioral disturbances in a mouse model of pediatric autoimmune neuropsychiatric disorders associated with streptococcal infection

ParameterGABHS donor micea (n=6–32)Recipients of nondepleted GABHS donor serab (n=3–9)Recipients of IgG-depleted GABHS donor serac (n=3–7)
Rotarod
 Time on rod
 Fall speed
    
Open field
 Vertical plane stereotypy moves (rearing)d
    
Resident–intrudere
 Exploration(↓)(↑)
 Social investigation(↓)(↑)
 Submission(↑)(↓)
 Defensive-escape(↑)(↓)
    
Olfactory learning
 HabituationNDND
 DiscriminationNDND
    
Reversal learning and memory
 Acquisition phase (day 3)   
  Working memory ratiodNDND
  Task errorsdNDND
  Interresponse timedNDND
 Probe trial   
  Working memory ratiodNDND
  Reference memory ratiodNDND
  Latency to first baited holedNDND
    
Brain regions with IgG deposits
 Cerebellum
 Striatum
 Hippocampus
 Periventricular area
  1. Abbreviations: GABHS, group A β-hemolytic streptococcus; IgG, immunoglobulin G; —, no significant differences or trends for that parameter; ND, not determined.
  2. Arrows indicate direction of effect in the first group relative to the indicated comparison group, where significant. Arrows within parentheses indicate direction of nonsignificant trends.
  3. a GABHS donor mice, as compared with PBS donor mice.
  4. b Nondepleted GABHS donor sera recipient mice, as compared with nondepleted PBS donor sera recipient mice.
  5. c IgG-depleted GABHS donor sera recipient mice, as compared with nondepleted GABHS donor sera recipient mice.
  6. d Effect observed in males only.
  7. e Females not tested.