Figure 8

From: Passive transfer of streptococcus-induced antibodies reproduces behavioral disturbances in a mouse model of pediatric autoimmune neuropsychiatric disorders associated with streptococcal infection

Figure 8

Increased repetitive rearing behavior in recipient mice injected with group A β-hemolytic streptococcus (GABHS) donor sera. Naive male SJL/J mice were injected with either pooled GABHS or phosphate-buffered saline (PBS) donor sera, or immunoglobulin G (IgG)-depleted GABHS or PBS donor sera. In open-field tests, mice injected with nondepleted GABHS donor sera showed increased repetitive rearing behaviors (vertical plane stereotypy moves) as compared with mice receiving IgG-depleted GABHS donor sera (Mann–Whitney U; *P<0.05) and tended to rear more than recipients of nondepleted PBS donor sera (Mann–Whitney U; P=0.058). Rearing counts of mice receiving IgG-depleted GABHS donor sera did not differ from those observed in mice receiving either nondepleted or IgG-depleted PBS donor sera. Height of box plot shows interquartile range; horizontal line, median; error bars, range; circles, outliers.