Figure 5

From: Passive transfer of streptococcus-induced antibodies reproduces behavioral disturbances in a mouse model of pediatric autoimmune neuropsychiatric disorders associated with streptococcal infection

Figure 5

Superior spatial and reversal learning and memory performance in male group A β-hemolytic streptococcus (GABHS) donor mice. Working and procedural memory capacity of GABHS and phosphate-buffered saline (PBS) donor mice were tested in a reversal spatial learning paradigm (hole-board memory task with 4-day acquisition phase followed by a single reversal probe trial on the fifth day). During the acquisition phase, GABHS donor males (closed circles) had greater working memory ratio (a), made fewer task errors (b) and exhibited reduced interresponse time (IRT) intervals (c) as compared to PBS donor males (open circles) (training day 3, Mann–Whitney U; **P<0.01). Error bars represent 95% confidence intervals. At the reversal task, administered in a single probe trial on the fifth day (at the start of the probe trial, mice are positioned so that they face the direction opposite to the starting direction used in all acquisition trials; start sites are defined relative to the physical location of the single baited hole), GABHS donor mice had greater working memory (d) and reference memory ratios (e) relative to PBS donors and found the first baited hole more quickly (f) (Mann–Whitney U, *P<0.05). Height of box plot shows interquartile range; horizontal line, median; error bars, range; circles, outliers.