Figure 3

From: Passive transfer of streptococcus-induced antibodies reproduces behavioral disturbances in a mouse model of pediatric autoimmune neuropsychiatric disorders associated with streptococcal infection

Figure 3

Reduced territoriality and increased passive behaviors in male group A β-hemolytic streptococcus (GABHS) donor mice in a social interaction test. Exploration of cage environment (a), social investigation (b), submission (c) and defensive-escape (d) behaviors of male GABHS and phosphate-buffered saline (PBS) donor mice were tested in a social interaction (resident–intruder) paradigm. Cage exploration and social investigation were reduced in resident GABHS donor mice as compared to resident PBS mice (Mann–Whitney U; *P<0.05, **P<0.005). Submissive and defensive-escape behaviors were increased in GABHS donor mice in the resident role as compared to PBS mice in the resident role (Mann–Whitney U; *P<0.05, **P<0.005). Height of box plot shows interquartile range; horizontal line, median; error bars, range; circles, outliers.