Figure 2

From: Passive transfer of streptococcus-induced antibodies reproduces behavioral disturbances in a mouse model of pediatric autoimmune neuropsychiatric disorders associated with streptococcal infection

Figure 2

Increased repetitive rearing behaviors in male group A β-hemolytic streptococcus (GABHS) donor mice. Repetitive motor behaviors of GABHS and phosphate-buffered saline (PBS) mice were measured in an open-field paradigm. Data are presented as the number of vertical plane stereotypy moves (rearing) exhibited by mice at the first post-immunization time point, normalized to the number of vertical plane stereotypy moves observed at preimmunization baseline. Normalized rearing moves were increased in male GABHS donor mice as compared to male PBS mice (Mann–Whitney U; *P<0.05). Height of box plot shows interquartile range; horizontal line, median; error bars, range; circles, outliers.