Depletion of adult hippocampal neurogenesis does not modify depression-related behaviors such as the novelty-suppressed feeding (NSF) test and the forced swim test (FST). (a) During the NSF test, the latency to feed in control-Dox mice (CD) and bigenic-Dox mice (BD) was similar (t17=−0.008, P=0.99). In the FST, the latency to immobility (b, t17=−0.17, P=0.87) and the time of floating (c, t17=−1.188, P=0.1) in control-Dox mice (CD) and bigenic-Dox mice (BD) were similar. White bar=CD. Black bar=BD.