Piccolo regulates dopamine transporter internalization via PIP2

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Two left upper panels show that piccolo is not colocalized with tyrosine hydroxyls (TH)-positive neurons. Two left middle panels show that piccolo is colocalized with dopamine transporter (DAT)-positive neurons. Bottom three panels show piccolo C2A domain (left; green), dopamine transporter (middle; red) and merge image (right). Most upper right panel is docking simulation between piccolo C2A domain and PIP2 under Ca2+ present condition. The right middle panel shows the piccolo C2A domain is colocalized with dopamine transporter in normal condition. For more information on this topic see the paper by Cen et al. on pages 451–463.

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