Keratocystic odontogenic tumor. Keratocystic odontogenic tumor has some very distinctive findings that are easily recognized. The squamous epithelial lining of this cystic tumor demonstrates an important finding: a distinct basal layer of cells, which has palisaded architecture. There is parakeratosis, also a critical histologic finding. Note that there is surface corrugation in some areas. Commonly seen in keratocystic odontogenic tumor is the separation of the epithelium from its underlying stroma. Although not a diagnostic feature, this finding is typical of this cystic tumor and its appearance, which can be readily seen at very low microscopic power, should lead to closer examination of the epithelium for findings of keratocystic odontogenic tumor.