Table 3: Transcripts differentially upregulated and downregulated in Hodgkin and Reed-Sternberg cells of classical Hodgkin lymphoma compared with tumor cells of ALK anaplastic large cell lymphomaa

From: A novel immunohistochemical classifier to distinguish Hodgkin lymphoma from ALK anaplastic large cell lymphoma

Fold changeGene symbolGene name
39.8CCL22Chemokine (C-C motif) ligand 22
26.4MMP12Matrix metallopeptidase 12 (macrophage elastase)
11.7CHI3L1Chitinase 3-like 1 (cartilage glycoprotein-39)
9.9TUBB2BTubulin, beta 2B
9.1PTGDSProstaglandin D2 synthase 21 kDa (brain) /// prostaglandin D2 synthase 21 kDa (brain)
8.4CD83CD83 molecule
8.2
7.6IL1R2Interleukin 1 receptor, type II
5.3MCOLN2Mucolipin 2
4.7SLC2A6Solute carrier family 2 (facilitated glucose transporter), member 6
4.5EBI3Epstein–Barr virus induced gene 3
4.2STAT3Signal transducer and activator of transcription 3 (acute-phase response factor)
3.9STAT5ASignal transducer and activator of transcription 5A
3.8SOCS3Suppressor of cytokine signaling 3
3.7APBB1IPAmyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein
3.6RAB13RAB13, member RAS oncogene family
3.5BASP1Brain abundant, membrane attached signal protein 1
3.4IER3Immediate early response 3
−1.9HIST1H4CHistone 1, H4c
−2.0
−2.2CDNA FLJ37566 fis, clone BRCOC2002085
−2.2EEF1DEukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
−2.3RPS27Ribosomal protein S27 (metallopanstimulin 1)
−2.3RPS10Ribosomal protein S10
−2.5RNPS1RNA binding protein S1, serine-rich domain
−2.7NDUFA6NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 6, 14 kDa
−2.9SAC3D1SAC3 domain containing 1
−3.2ATP6V0EATPase, H+ transporting, lysosomal 9 kDa, V0 subunit e
−3.4LOC653784Similar to hypothetical protein FLJ14346
−3.5NDUFA4NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4, 9 kDa
−3.5BTBD6BTB (POZ) domain containing 6
−3.9Transcribed locus, strongly similar to XP_511906.1 PREDICTED: similar to KIAA0612 protein [Pan troglodytes]
−5.0CAPN2Calpain 2, (m/II) large subunit
  1. P-value <0.05, false discovery rate <0.1.
  2. aModified from Eckerle et al.20