Tumor content for biopsies collected as part of the Q-CROC-01 study. (a) Flow chart of patients from whom two liver needle core biopsies were collected in RNAlater. (b) Tumor content (%) in liver biopsies for 42 patients participating in the Q-CROC-01 study. Patients marked by an asterisk (*) are those whose biopsy tissue were not histologically consistent with colorectal cancer. Patients marked by a diamond (♦) did not undergo the biopsy procedure. (c) Section from patient 021 (Biopsy-1) showing a clear boundary between normal and tumor tissue. (d) Tumor region in the same core, showing neoplastic cells and stroma. (e) Tumor region in Biopsy-1 from patient 018 exemplifying a specimen not suitable for macrodissection.