Figure 5 | Modern Pathology

Figure 5

From: Loss of 5-hydroxymethylcytosine correlates with increasing morphologic dysplasia in melanocytic tumors

Figure 5

5-hydroxymethylcytosine highlights nevic component within a melanoma. Conventional histology of a case of superficial spreading melanoma arising within a benign dermal nevus (left column, hematoxylin and eosin). 5-hydroxymethylcytosine immunohistochemistry stain (right column) show negativity in the superficial malignant melanoma components and positivity in dermal nested nevic components (right column). The black arrow highlights the nevic nests and red arrow indicates the larger melanoma cells surrounded by inflammation.

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