Table 4 Associations of clinical and pathologic factors with BAP1 expression by immunohistochemistry

From: Genetic and clinico-pathologic analysis of metastatic uveal melanoma

Factor Level BAP1-negative, N (%) BAP1-positive, N (%) P-value
Age at primary (years) <57.7 8 (50) 3 (19) 0.51
  >57.7 5 (31) 0  
Age at metastasis (years) <60 6 (38) 3 (19) 0.21
  >60 7 (44) 0  
Sex Female 7 (44) 1 (6) 1.00
  Male 6 (38) 2 (13)  
Status at last follow-up Alive 0 1 (6) 0.10
  Dead of UM 10 (63) 2 (13)  
  Dead not of UM 2 (13) 0  
Mutation Wild type 3 (19) 0 0.54
  GNA11 mut 9 (56) 3 (19)  
  GNAQ mut 1 (6) 0  
Metastasis site Skin/soft tissue 8 (50) 0 0.43
  Viscera 5 (31) 1 (6)  
Cell type Spindle 1 (6) 0 1.00
  Epithelioid/mixed 12 (75) 3 (19)  
Pleomorphism Uniform 9 (56) 2 (13) 1.00
  Pleomorphic 4 (25) 1 (6)  
Pigment Absent 3 (19) 1 (6) 0.36
  Focal 5 (31) 0  
  Moderate 3 (19) 2 (13)  
  Diffuse 2 (13) 0  
Melanophages Absent 8 (50) 1 (6) 0.65
  Rare 3 (19) 1 (6)  
  Frequent 2 (13) 1 (6)  
TILs Absent 6 (38) 3 (19) 0.24
  Mild 4 (25) 0  
  Moderate 3 (19) 0  
LVI Absent 10 (63) 3 (19) 1.00
  Present 3 (19) 0  
PNI Absent 13 (81) 2 (13) 0.19
  Present 0 1 (6)  
  1. Abbreviations: IHC, immunohistochemistry; LVI, lymphovascular invasion; PNI, perineural invasion; TILs, tumor-infiltrating lymphocytes; UM, uveal melanoma.