Table 1 Correlation of molecular markers and reovirus infection in the melanoma cell line SK-Mel28

From: Reovirus-associated reduction of microRNA-let-7d is related to the increased apoptotic death of cancer cells in clinical samples

Marker No reovirus (mean (s.d.)) a Reovirus (mean (s.d.)) P-value (reovirus vs no treatment)
PKR 0.3 (0.5)b 7.0 (1.0) <0.0001
pERK 1.0 (1.0) 9.6 (1.5) <0.0001
Ras 5.3 (2.5) 49.3 (1.1) <0.0001
Caspase-3 1.6 (1.0) 6.8 (0.7) <0.0001
TUNEL 0.4 (0.5) 5.0 (0.8) <0.0001
  1. Abbreviations: PKR, protein kinase RNA-activated (also known as interferon-inducible RNA-dependent protein kinase; the phosphorylated form was detected; pERK, extracellular-signal-regulated kinases; the phosphorylated form was detected.
  2. as.d.
  3. bThe values are the percentage of positive cancer cells and represent a minimum of n=3 and a tabulation of at least 350 cells.