Figure 1 | Modern Pathology

Figure 1

From: ALK alterations in adult renal cell carcinoma: frequency, clinicopathologic features and outcome in a large series of consecutively treated patients

Figure 1

Interphase fluorescence in situ hybridization to identify the rearrangement of anaplastic lymphoma kinase (ALK) using a commercially available ALK break-apart probe (Abbott Molecular) on the tumor from patient 1. Abnormal tumor cells show one red (R), one green (G), and one fusion (F) signal pattern indicating one rearranged ALK gene (white arrows) and one intact ALK gene.

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