Table 3 Correlation of clinical and pathological findings of 28 intramuscular myxomas with and without GNAS1 mutations

From: GNAS1 mutations occur more commonly than previously thought in intramuscular myxoma

  Series of myxoma Tumours with GNAS1 mutations Tumours without GNAS1 mutations
Size (mean) of myxoma 55 mm 58 mm 53 mm
Classical variant 56 mm 55 mm 43 mm
Cellular variant 64 mm 54 mm 69 mm
Size (range) of myxoma 25–110 mm 30–95 mm 25–110 mm
Classical variant 25–100 mm 35–70 mm 25–100 mm
Cellular variant 28–110 mm 35–95 mm 28–110 mm
Male (class:cellular) 12 (9:3) 7 (6:1) 5 (2:3)
Female (class:cellular) 16 (8:8) 10 (7:3) 6 (2:4)
Age range (mean) yrs (class:cellular) 54 (30–83) 56 (30–83) 57 (40–76)
Thigh (class:cellular) 18 (10:8) 11 (7:4) 7 (3:4)
Arm (class:cellular) 6 (6:0) 4 (4:0) 2 (1:1)
Buttock (class:cellular) 4 (1:3) 2 (2:0) 2 (0:2)
  1. Class, classical variant; cellular, cellular variant.
  2. There was no significant difference between any of the clinical correlates and tumour details when analysed as a group of all tumours or when separated into the classical and cellular variants with and without GNAS1 mutations.
  3. Two cases were associated with fibrous dysplasia (Mazabraud's syndrome).