Figure 4 | Mucosal Immunology

Figure 4

From: AIM2 contributes to the maintenance of intestinal integrity via Akt and protects against Salmonella mucosal infection

Figure 4

Absent in melanoma-2 (AIM2) deficiency leads to perturbed epithelial cell proliferation and apoptosis following Salmonella oral challenge. (a) Immunofluorescence was performed on cecum sections derived from wild-type (WT) and AIM2−/− mice on day 2 post Salmonella oral infection for the examination of proliferating cells (PCNA). (b) Apoptotic cells were identified in the cecum by terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling (TUNEL) staining. (c) Levels of cleaved caspase-3 expression in cecum lysates were determined by immunoblotting. Magnification, × 200.

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