SFB and arthritis

In News and Highlights, Charlotte Kaetzel examines a recent study demonstrating an essential role for segmented filamentous bacteria in the development of autoimmune arthritis in a murine model driven by autoantibodies and T helper type 17 cells. See page 536

iBALT and immunity in the lung

Inducible bronchus-associated lymphoid tissue (iBALT) develops in response to infection and inflammation. Shen Yun Foo and Simon Phipps discuss the generation and function of this unique ectopic immune compartment. See page 537

Topical immunization

Cecil Czerkinsky and Jan Holmgren address topical vaccine strategies to target mucosal infections at various anatomical sites. See page 545

Mucosal adjuvants and memory

Nils Lycke and Mats Bemark discuss how adjuvants from the adenosine diphosphate–ribosylating toxin family can be effective in driving long-term B- and T-cell memory responses that are key to mucosal vaccine efficacy. See page 556

T-bet in mucosal homeostasis

Nicholas Powell and coauthors review findings indicating an essential role for the transcription factor T-bet (T-box factor expressed in T cells) in regulating innate and adaptive immunity at mucosal surfaces. See page 567

Myeloid-suppressor cells control Th2 responses in the lung

Meenakshi Arora and colleagues show that lipopolysaccharide exposure controls house dust mite–driven airway eosinophilia and T helper type 2 cytokine production by driving the development of suppressive CD11bGr1F4/80 cells. See page 578

T-cell phenotypes in celiac disease

Michael Bodd and colleagues demonstrate that gluten-reactive, tetramer-positive CD4+ T cells from the peripheral blood and small-intestine biopsies of patients with celiac disease produce interleukin (IL)-21 and interferon-γ, but not IL-17 or IL-22, as has been suggested by others. See page 594

Psoriasin defends against E. coli

Michael Mildner et al. identify psoriasin (S100A7) in human vaginal fluid as a major factor in innate defense against Escherichia coli. See page 602

First cloning of equine J chain and pIgR

Melanie Lewis and colleagues report the initial cloning of equine J chain and polymeric immunoglobulin receptor (pIgR). They also generated recombinant forms of equine immunoglobulin A and secretory component and analyzed their interaction. See page 610

Epithelial cell sensing of rotavirus

Amena Frias and co-workers show that type I interferon–dependent antiviral responses in intestinal epithelial cells are independent of viral replication but require both viral structural proteins and viral RNA. See page 622

CrmD attenuates TNF-driven colitis

Abel Viejo-Borbolla and colleagues demonstrate that intestinal expression of ectromelia virus cytokine response modifier D (CrmD), a protein that binds tumor necrosis factor (TNF)-α and some chemokines, was able to attenuate colitis development in TNFARE mice. See page 633