SFB and arthritis
In News and Highlights, Charlotte Kaetzel examines a recent study demonstrating an essential role for segmented filamentous bacteria in the development of autoimmune arthritis in a murine model driven by autoantibodies and T helper type 17 cells. See page 536
iBALT and immunity in the lung
Inducible bronchus-associated lymphoid tissue (iBALT) develops in response to infection and inflammation. Shen Yun Foo and Simon Phipps discuss the generation and function of this unique ectopic immune compartment. See page 537
Topical immunization
Cecil Czerkinsky and Jan Holmgren address topical vaccine strategies to target mucosal infections at various anatomical sites. See page 545
Mucosal adjuvants and memory
Nils Lycke and Mats Bemark discuss how adjuvants from the adenosine diphosphate–ribosylating toxin family can be effective in driving long-term B- and T-cell memory responses that are key to mucosal vaccine efficacy. See page 556
T-bet in mucosal homeostasis
Nicholas Powell and coauthors review findings indicating an essential role for the transcription factor T-bet (T-box factor expressed in T cells) in regulating innate and adaptive immunity at mucosal surfaces. See page 567
Myeloid-suppressor cells control Th2 responses in the lung
Meenakshi Arora and colleagues show that lipopolysaccharide exposure controls house dust mite–driven airway eosinophilia and T helper type 2 cytokine production by driving the development of suppressive CD11bGr1F4/80 cells. See page 578
T-cell phenotypes in celiac disease
Michael Bodd and colleagues demonstrate that gluten-reactive, tetramer-positive CD4+ T cells from the peripheral blood and small-intestine biopsies of patients with celiac disease produce interleukin (IL)-21 and interferon-γ, but not IL-17 or IL-22, as has been suggested by others. See page 594
Psoriasin defends against E. coli
Michael Mildner et al. identify psoriasin (S100A7) in human vaginal fluid as a major factor in innate defense against Escherichia coli. See page 602
First cloning of equine J chain and pIgR
Melanie Lewis and colleagues report the initial cloning of equine J chain and polymeric immunoglobulin receptor (pIgR). They also generated recombinant forms of equine immunoglobulin A and secretory component and analyzed their interaction. See page 610
Epithelial cell sensing of rotavirus
Amena Frias and co-workers show that type I interferon–dependent antiviral responses in intestinal epithelial cells are independent of viral replication but require both viral structural proteins and viral RNA. See page 622
CrmD attenuates TNF-driven colitis
Abel Viejo-Borbolla and colleagues demonstrate that intestinal expression of ectromelia virus cytokine response modifier D (CrmD), a protein that binds tumor necrosis factor (TNF)-α and some chemokines, was able to attenuate colitis development in TNFARE mice. See page 633
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In this Issue. Mucosal Immunol 3, 535 (2010). https://doi.org/10.1038/mi.2010.63
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DOI: https://doi.org/10.1038/mi.2010.63