Since the invention of optical tweezers, optical manipulation has advanced significantly in scientific areas such as atomic physics, optics and biological science. Especially in the past decade, numerous optical beams and nanoscale devices have been proposed to mechanically act on nanoparticles in increasingly precise, stable and flexible ways. Both the linear and angular momenta of light can be exploited to produce optical tractor beams, tweezers and optical torque from the microscale to the nanoscale. Research on optical forces helps to reveal the nature of light–matter interactions and to resolve the fundamental aspects, which require an appropriate description of momenta and the forces on objects in matter. In this review, starting from basic theories and computational approaches, we highlight the latest optical trapping configurations and their applications in bioscience, as well as recent advances down to the nanoscale. Finally, we discuss the future prospects of nanomanipulation, which has considerable potential applications in a variety of scientific fields and everyday life.
Optical manipulation (OM), such as optical cooling1, trapping2, binding3, 4, 5, sorting and transporting6, 7 by utilizing optical forces, has experienced intensive development in the past 40 years. OM is currently one of the most important tools in many scientific areas, including optics8, atomic physics9, 10, biological science11 and chemistry12. Recently, with the rapid progression of nanotechnology, novel features and trends of OM have made great progress at subwavelength and nanometer scales.
In traditional OM studies, the configuration of a dielectric or metallic sphere in the focus of a light beam is usually investigated by considering the scattering of its fundamental mode, which is often Gaussian. Recently, however, OM has gone beyond this scenario, and complex configurations have been investigated. For example, OM resolution has been increased beyond the Rayleigh limit by extending it to the near-field, thus taking advantage of non-radiative optical waves13. The manipulated object can be magneto-dielectric14, chiral15 or multilayer coated16, 17 rather than a single dielectric body. In addition, the object may be asymmetric, such as a rotator or gearwheel. Meanwhile, the incident light is usually composed of special wavefields, such as non-diffraction Bessel beams stemming from multiple beam interference, or more complex light fields generated by a spatial light modulator. A representative example is the recently proposed optical tractor beams18, 19, 20, 21, 22, 23, 24, which can exert a negative radiation pressure, or non-conservative force, on a body, thus pulling it towards the light source25.
In addition, when objects are resonant with the incident light26, the optical force may be greatly enhanced. In this way, when a single structure simultaneously supports both optical and mechanical resonances, novel phenomena can be expected and achieved27. Photonic forces on nanoparticles have recently been related to the fundamental van der Waals and Casimir interactions28, 29, 30, 31, 32, and it has been shown how stochastic photonic forces can be created and tailored by appropriately designing and controlling the coherence and statistical properties of fluctuating optical sources33. Using OM as a powerful tool, many new applications have been demonstrated in biochemical research for biological cell constituents, DNA and biopolymers34, 35, 36.
Although several excellent articles have reviewed various aspects of OM37, 38, 39, 40, 41, 42, 43, this tool has rapidly developed in diverse domains, especially during the past few years. New achievements have emerged and have affected various scientific fields. In this review, we attempt to provide a full picture of the latest advances in OM as well as insights and perspectives for future applications, ranging from the now century-old fundamental dilemma of photon momentum transfer in media to applications on micrometer-sized or smaller objects and structures, which have recently attracted considerable attention. We start with the fundamental computations of optical force and then emphasize the recently developed OM tractor beams, plasmonic nanotweezers and biochemical applications. First, we present a detailed description of the physical origins, nature and determinations of optical forces, which are useful to probe the underlying physical aspects of momentum transfer. Thereafter, we review the OM of structured beams based on optical pulling, optical rotation and optical binding. Then, approaches to enhance the optical force on nanoscale particles by plasmonics are presented, and applications of OM in life sciences, such as in biological cells, DNA and other types of biopolymers, are discussed. Finally, our perspective of future OM developments and potential applications is presented.
Fundamentals of optical forces and computational approaches
We start this section with a discussion of the nature of the optical force on particles, that is, the physical origin and calculation approaches. Generally, this force is a consequence of a change in momentum carried by photons1, 2, 44. When a particle is micrometer-sized or smaller, the dominant mechanical actions are radiation pressure and the Lorentz force, not gravitational forces. In 1619, Kepler first suggested that the pressure of light causes comet tails to always point away from the Sun45, 46. This theory was extended by Maxwell and was confirmed experimentally by Nicolas and Hull45, 46. However, the concept that electromagnetic fields or photons carry momentum led to several problems. For example, the magnitude of radiation pressure is conveniently expressed in the form of momentum carried by a single photon46. With this concept well understood in free space46, researchers naturally considered its counterpart in matter46, 47, especially inside a body47, because almost all OM schemes address objects suspended in a fluid or linked to a solid. The ensuing debate on photon momentum p in matter, known as the Abraham–Minkowski and related controversies in electrodynamics, is whether one should write momentum as
where ħ is the reduced Planck’s constant, ω represents the angular frequency of light, c is the speed of light in vacuum and n denotes the refractive index of the background medium. A possible resolution of this problem regarding photon momentum was proposed by Barnett48, who argues that pMin and pAbr describe two entirely different concepts. Total momentum is always a single conserved quantity, where Minkowski’s photon momentum is the canonical momentum of a photon and Abraham’s photon momentum is the kinetic momentum of a photon48.
Consequently, the calculation of the total optical force on a body embedded in a medium has different versions, which can be derived by integrating the momentum flux over any closed surface σ surrounding this object. The time-average force on a particle of any size is49, 50
where is the Maxwell stress tensor, n is the outward normal to the surface σ and 〈·〉 represents the time-average operation. Initially, Minkowski51, 52 suggested that a field energy-momentum tensor should preserve its form in all Lorentz frames. According to him, the Maxwell stress tensor should be
where Î is the unit tensor. This stress tensor was derived from the optical momentum transfer from the background to the embedded body. Several experiments have supported Minkowski’s theory. Experimental data in favor of the Minkowski formulation are found in detail in Refs 48, 53, 54.
Experiments supporting the Abraham formulation can be found in detail in Refs 45, 58, 59, 60. The controversies in the area of optical force calculation can be resolved if the corresponding ranges of validity of the optical force formulations are clearly identified14, 61, 62, 63. However, in most configurations addressing time-averaged forces, as reviewed in this paper, both theories yield the same time-averaged optical force54. In fact, the difference between Minkowski’s force and Abraham’s force arises mainly in the time domain54. There are approaches other than Equation (2), for example, using different force density methods64. However, in several experiments where in the background was considered as a material medium rather than air or vacuum, the different volumetric force formulations predicted distinct magnitudes of the time-averaged force on an embedded scatterer63. Therefore, the formulations of Minkowski and Abraham are considered the most reliable approaches for the time-averaged force on objects of any size or shape54.
Early in the 1970s, optical forces from focused laser beams, which could accelerate and trap particles at the micron scale, were observed in experiments2. There are two basic components of force in optical tweezers: gradient force and scattering force. The gradient force comes from the intensity gradient of the electric field of the focused beam, and the scattering force is caused by the optical momentum of the light transferred to the particle. The conservative gradient force points to the position of the electric intensity maxima, whereas the non-conservative scattering force from beams pushes the object along the propagation direction. The balance between these two forces produces an equilibrium point near the focus. Optical tweezers, based on field gradients, rely on changing this equilibrium point to manipulate trapped bodies in three dimensions. Optical tweezers have multiple applications in biological and physical sciences.
In general, an illuminated dipolar magneto-dielectric particle can develop electric and magnetic dipole moments in response to an electromagnetic field65. Hence, the resulting optical forces can be regarded as the sum of forces exerted on the induced dipoles and the interaction between the electric and magnetic dipoles. Compared with the method that integrates the Maxwell stress tensor on the surface of objects, this decomposition helps us to understand the different contributions of an external electromagnetic field to the optical force. In the following paragraphs, we consider a magneto-dielectric nanoparticle with constitutive parameters ɛp and μp, embedded in a non-absorbing medium with permittivity ɛ, permeability μ and refractive index . This object is illuminated by an incident field with electric and magnetic vectors Ei and Bi. A harmonic time dependence exp(−iωt) is assumed throughout. The time-averaged total electromagnetic force on the particle is given by the Minkowski stress tensor50
where the asterisk denotes a complex conjugate, S is any surface that encloses the particle and n is its local unit outward normal. The electric and magnetic fields in Equation (5) are total fields, that is, Ei+E(s) and Bi+B(s). For the flow evaluation of the outside surface enclosing an object and assuming the embedding background is a linear homogeneous isotropic medium, the Minkowski and Abraham stress tensors coincide.
If the object is considered as dipolar in the wide sense (the particle size is much smaller than λ/n, where λ is the incident wavelength in the background medium), its electric and magnetic polarizabilities αe and αm can be written in terms of the coefficients a1 and b1 of the first Mie electric and magnetic partial waves as follows: , and k=nω/c. Then, the ith Cartesian component of the averaged force may be expressed in the following form:14, 66
where p and m denote the electric and magnetic dipole moments of the particle induced by the incident field, p=αeE(i) and m=αmB(i), respectively. In Equation (6), Einstein’s summation convention is understood over all repeated indices. The three terms of Equation (6) represent the forces due to the induced dipoles: electric <Fe>, magnetic <Fm> and interference <Fe–m> between them. The interference component is associated with the asymmetry of the particle’s differential scattering cross-section or angular distribution of the scattered intensity under a plane wave or Gaussian beam illumination. This effect in turn is related to interesting scattering effects, such as the emission of zero-backward (when ɛ−1αe=μαm) or almost zero-forward scattered intensity (when Re(ɛ−1αe)=−Re(μαm) and Im(ɛ−1αe)=Im(μαm))67, known as the first and second Kerker conditions, respectively68, 69, 70, 71.
The three components <Fe>, <Fm> and <Fe–m> of Equation (6) for a general magneto-dielectric dipolar particle may also be written in more explicit form as follows14:
where 〈Ue,m〉 is the time-average of the electric (magnetic) energy density, 〈LSe,Sm〉 is the electric (magnetic) spin density of the optical field and 〈S〉 stands for the Poynting vector14
The first terms of Equations (7) and (8) are the gradient components that are responsible for electric and magnetic optical tweezers. The remaining terms constitute non-conservative electric and magnetic forces and . The second term describes the radiation pressure or scattering component expressed by the time-averaged energy flow. This term is the only contributing one if the incident wave field reduces to a plane wave. The third term accounts for the curl force due to spin72, 73.
The time-average Poynting vector can be decomposed into the sum of time-averages of the electric orbital momentum density and spin momentum density 74 or alternatively as the sum of the magnetic orbital momentum density and spin momentum density as follows:
From Equations (7),(8) (11) and (12), one can identify the non-conservative component of the forces from the electric and magnetic dipoles as proportional to the respective electric and magnetic orbital momentum densities, that is, ; . Alternatively, the electric and magnetic non-conservative optical forces can be represented in terms of the classical radiation pressure expressed by the linear momentum density or Poynting vector 〈S〉 that characterizes the energy flow plus the curl of the spin density. For the latter case, the introduction of the linear momentum 〈S〉 automatically arises in the non-conservative forces due to the appearance of the electric or magnetic spin momentum densities . Whereas the action of the orbital momentum is physically well understood, the role of the spin momentum is a subject of active study. Equations (11) and (12) show the interference force < Fe–m>, given by the imaginary part of E × B*, which characterizes the ‘reactive’ or ‘stored energy’ and its alternating flow50. These two equations show that in addition to the linear momentum 〈S〉, contains a new momentum Re(E*·∇)E whose significance is still being studied75.
Magneto-dielectric particles were previously considered hypothetical and difficult to obtain in nature. On the basis of a magneto-dielectric material, unusual zero backscattering or minimum forward-scattering effects were predicted at certain wavelengths by Kerker et al.69 as a consequence of the interaction between the electric and magnetic dipoles. It is possible to build blocks of metamaterials76, scatterers or optical antennas due to their unique emission directionality properties. Recent works have shown that dielectric spheres of relatively high refractive index np behave as magneto-dielectric particles and exhibit a remarkably scaling property. According to their scattering cross-section, these magneto-dielectric particles are fully characterized by the excitation of either their electric or magnetic dipoles, associated with the Mie coefficients a1 and b1, respectively, at constant values of the size parameter y=npka. If np varies, either k or a may be changed accordingly, leaving the value of size parameter at which those excitations appear unchanged. Such dipoles may equally appear in semiconductor particles by incident waves in either the visible or near-infrared ranges (depending on their sizes) or in ceramics in the microwave range. Such magneto-dielectric nanoparticles, with the corresponding theory of optical forces established as shown above, offer a new twist for OM77.
As an example, we consider a silicon sphere of radius a=230 nm and ɛp=3.5 in a vacuum (ɛ=μ=1) illuminated by a plane wave of unit amplitude. The time-averaged optical force it experiences is purely a non-conservative scattering force14,
The three terms of Equation (13) correspond to the aforementioned components < Fe>, < Fm> and < Fe–m>, respectively. The magnitudes of the magnetic term < Fm> and the electric–magnetic interference term < Fe–m> contribution to the time-averaged total forces have peaks in the region of the magnetic dipole resonance, as shown in Figure 1a and 1b. Under the first Kerker condition (zero backscattering differential cross-section, see the second vertical line in Figure 1b), < Fe>=< Fm>=−< Fe–m>, so the resulting force represents a particle with a purely electric or magnetic dipole. For a plane wave, the negative < Fe–m> cannot overcome the positive < Fe>+< Fm>. However, as shown in the next section, the positive terms of the electric and magnetic components are overcome by the interference term for a Bessel beam, which in this way constitutes a tractor beam.
By contrast, under the second Kerker condition (minimum forward-scattering differential cross-section, see the first vertical line in Figure 1b), the three force components reinforce each other because they are all positive. There are also regions of the spectrum, Re(αe)<<Im(αe) and Re(αm)<<Im(αm), where the corresponding dipolar scattering force has larger values. These regions have recently been observed in an experiment78. This situation is opposite to those of conventional nano-optical tweezers, whereby gradient forces, rather than the radiation pressure, are dominant.
Non-conservative forces and optical torque
In the past decade, ‘tractor beams’ that drag trapped objects towards a light source, have attracted substantial attention19, 20, 21, 79, 80. Except for gain materials20, 81, 82, due to momentum conservation, the optical force for paraxial illumination is positive, namely, it pushes the object away from the light source. Recently, however, several exotic light structures have been proposed to trap objects moving towards a light source, such as optical vortex beams83, optical solenoid beams84, gradientless Bessel beams18, 21, 22, 85, 86, structured nondiffracting beams19, 20 and holographic optical beams87, 88, 89, 90, 91, 92.
It has been demonstrated20 that there is a region of negative optical force (NOF) for a class of designed optical beams (Figure 2a). The NOF is located in the vicinity of a local intensity minimum and acts up to long distances along the propagation direction of the illuminating wave. However, the regions of the NOF are small compared to the incident wavelength. Thus, a nondiffracting beam constituted by 24 plane waves with the same kz component was used19. According to the conservation of linear momentum, the polarization and phase of the plane waves were optimized so that the differential scattering cross-section along the propagation direction was maximized. In this case, the total force on a cluster of 160 spheres was opposite to the direction of wave propagation. The structured nondiffracting beam could exert a negative optical force along the extent of the beam for objects of any shape or size. Meanwhile, an optical conveyor belt was built based on the standing wave formed through the interference of two counter-propagating Bessel beams93. Controlled delivery of objects over hundreds of micrometers in size was achieved by manipulating the relative phase of both Bessel beams. Alternatively, a negative optical force can be obtained by using a single nonparaxial Bessel beam with small projection of momentum in the light propagation direction18, 22, 85. Suitable particles can be pulled all the way to the light source using nonparaxial Bessel beams, known as ‘tractor beams’. Such beams are diffraction-free and can be realized in experiments94. Bessel beams also have a self-healing property, whereby the beam wavefront is restored after being scattered by an object, making long distance OM possible. The diffractionless and self-healing nature of Bessel beams can be utilized to simultaneously trap multiple particles in separated positions with only a single beam95. Similar to Bessel beams, the Airy beam is also nondiffracting and self-healing, but it experiences transverse acceleration96. It is this unique characteristic that can transport biological objects along a curved trajectory; thus, Airy beams could be used to clear biological cells from a chamber97.
where β is the longitudinal component of the wave vector, αe,m is the electric (magnetic) polarizability and pz=ez(Ei × Hi*). From Equation (14), one can see that a negative force requires a small longitudinal wave vector and a large pz in the forward direction, that is, a small input photon momentum and a large output momentum in the propagation direction. The scattering along the propagation direction can be simultaneously maximized due to the interference of radiation multipoles. Then, the optical force can be pulling (see Figure 2b). The time-averaged optical force can be divided into the incident term and the interference term85. The large recoil force from the interference term may overcome the force from the incident terms, resulting in an attractive optical force. In addition, particles with material parameters close to the zero-backward condition (ɛ=μ) also tend to be pulled by light beams because under these conditions, forward scattering is maximal. However, stable trapping requires not only a negative force in the axis direction but also in the radial direction, that is, the optical force should be on the beam axis and point towards the light source22. In this way, a particle around the beam axis may be attracted to the beam center and be pulled to the light source in stable trajectories (Figure 2c).For core–shell or hollow metallic particles, negative scattering force was found at Fano resonance, where the intensity of the forward scattering was much stronger than that of the backward scattering98. Hence, the enhanced forward scattering can give rise to a large recoil force. The incident and scattering light field can also be structured to obtain higher trapping stiffness. On the basis of the principle of maximal stiffness for a beam splitter, Taylor et al.99 demonstrated that structured scattering of particles improved the stiffness of optical trapping by ~30-fold. This approach could be a new way to perform OM.
Recently, experiments demonstrating tractor beams have been conducted. Lee et al. used an optical solenoid beam to trap and move a colloidal silica sphere against the direction of light propagation84. The solenoid beam exerted both intensity-gradient and phase-gradient forces on an object. By alternating the independent helical phase profile, the object could be transported downstream and retrograde upstream for a long distance. Similarly, the bidirectional transport of an optical conveyor was achieved by changing the relative phase of a Bessel beam21. This type of tractor beam has the potential to exert stable trapping with uniform speed, even on multiple objects. A tractor beam generated through the interference of a single Gaussian beam and its reflection also demonstrated the pulling effect24. Different sizes of particles can be sorted by switching between s- and p-polarized beams (Figure 2d). Subsequently, polarization-controlled tractor beams have been demonstrated to stably transport spherical particles for over tens of centimeters in gaseous environments100. For absorbing particles in a gaseous medium, the gas-dynamic force (that is, photophoretic force) is dominant compared to the optical force101. By controlling the polarization of incident light (radially polarized or azimuthally polarized), the heat source distribution on an Au-coated hollow dielectric sphere can be significantly changed, thus determining the direction of the photophoretic force100.
In addition to the optical forces directly arising from light–matter interactions, optical binding forces can emerge from the momentum exchange between multiple particles. Light-mediated optical binding offers a new method of self-assembly, organization and cell sorting. Moreover, the combination of scattering force and optical binding forces can produce stable optical trapping, even for a plane wave. Grzegorczyk et al.102 designed a trapping configuration with two series of fixed nanoparticles. The two walls of the nanoparticles interact with an incident plane wave and induce optical binding forces. By optimizing the locations of the fixed nanoparticles, they can create a potential well to stably trap one or more nanoparticles. Compared to microscale particles, stronger trapping forces are required to overcome the thermal forces for fine control of objects at the nanoscale. In the Rayleigh regime, both metallic and dielectric particles have similar scattering patterns103, so the gradient force is still a dominant factor for stable trapping of small particles in conventional optical tweezers. However, the optical binding forces of metallic nanoparticles have been found to be >20 times larger than the gradient force104, and they decayed slower than the gradient force105, which enables extremely stable nanometer manipulation. Hence, optical binding has potential applications in trapping small particles and assembling nanostructures. The spheroidal nanoparticles could arrange themselves into clusters, chains, photonic lattices and linear lines by optical binding, as shown in Figure 3a and 3b. Alternatively, computer-generated holographic tweezers can also be used to organize particles into such nanostructures in three dimensions (Figure 3c and 3d).
Because light carries not only linear momentum but also angular momentum (AM), the AM may be transported in optical tweezers to rotate particles in different ways (Figure 4a). In general, the torque from the transport of the linear momentum of incident waves is conservative and transient, whereas the torque due to the transport of AM is non-conservative and can continuously rotate particles with absorption, birefringence or asymmetry113, 114, 115, 116. As discussed in ‘Fundamentals of optical forces and computational approaches’, the AM of light has two forms: spin angular momentum (SAM) and orbital angular momentum (OAM). Both SAM and OAM can be conveyed to the particle through absorption and scattering117 and result in torque that rotates the object118, 119, 120, 121, 122, 123, 124. The mechanical effect of AM has transformed optical tweezers into optical spanners125, attracting attention for their various potential applications. Apart from the SAM and OAM of light, optical absorption is essential for a homogeneous isotropic spherical particle to experience torque. A photon can transfer both forms of AM to the absorbing particle. Using a custom magneto-optic manipulator, the torque on absorbing microspheres caused by the transfer of SAM is directly measured126. This torque can be used in OM, for example, ultrafast spinning at the frequency of several kHz of the absorbing gold nanoparticles irradiated by circularly polarized light has been achieved127. Rubinsztein-Dunlop and colleagues experimentally observed the rotation of absorptive particles due to the absorption of OAM from a singularity beam128. The absorbing particle experienced optical torque along the beam axis on which the incident AM was defined. The rotation direction reversed when the sign of the incident AM was changed129. However, absorption may cause unwanted thermal effects, obstructing stable particle trapping.
To create optical torque predominantly from scattering, the scattered light should be made to exhibit a twist in the azimuthal direction, which means the AM carried by the scattered beam should be different from that of the incident beam. The scattering-dominant optical torque can be enhanced by using multipolar plasmon resonance. The AM transfer between photons and flat symmetry-breaking nanostructures was theoretically studied, and it was shown that resonant scattering can contribute up to 80% of the optical torque117. The scattering-dominant optical torque makes it possible to manipulate microscale dielectric particles that have negligible absorption. Emile et al.109 used a torsion pendulum to demonstrate the transfer of OAM carried by an electromagnetic wave, which was generated by a pair of turnstile antennas, to a suspended copper ring in the microwave region. A negative torque (NOT) occurs due to AM conservation when the AM of the scattered light in the z-component is larger than that of the incident light (Figure 4b).
In addition, the conservation laws for spin and orbital angular momenta scattered by a small particle help us to understand the underlying physical nature of NOT130, 131. Conversion can occur in optically inhomogeneous anisotropic media, and the transformation of SAM to OAM may give rise to ‘left-handed’ torque132, 133, 134. An inhomogeneous and anisotropic macroscopic object (form-birefringent nanostructured glass plates) was recently used to demonstrate the left-handed mechanical effect, which rotates the object in the opposite direction of the incident AM134. As it is not easy to directly observe and rotate a macroscopic object, D Hakobyan combined the rotation with the rotational Doppler effect and identified the rotation direction of the macroscopic object using the spatiotemporal interferograms of the transmission beam with a reference beam. This counterintuitive mechanical effect is analogous to the abovementioned ‘tractor beams’ and may provide insights into the mechanism of the spin-orbit interaction.
There are several other ways to rotate objects, such as using birefringent particles, chiral structures and metallic nanowires110, 112, 135, as shown in Figure 4c and 4d. For stable rotation of metallic nanowires using the optical vortex shown in Figure 4d, the length of the metallic nanowires must be longer than the bright ring of the optical vortex. Higher topological charges of the optical vortex lead to larger bright rings112; hence, shorter nanowires cannot be rotated in the dark core of the optical vortex. More generally, an unsymmetric object, such as a nanorod or an oblate spheroid136, 137, 138, may experience torque (in addition to an optical force) when illuminated by a Gaussian beam (without AM) because the force distribution inside the object is inhomogeneous. Certainly, the torque will vanish when the equilibrium orientation and position are reached. The torque can be observed in micrometer-scale structures immersed in water and under the illumination of laser light139. This achievement was a big step towards the OM of microscopic objects.
Force enhancement by plasmonics at the nanoscale
Although conventional optical tweezers, based on focused propagating beams, have been extensively employed to manipulate micrometer objects, it is difficult to stably and accurately trap particles with radii much smaller than the wavelength. The precise manipulation of small particles at the nanoscale is crucial in biosciences and in atomic and material physics for handling living viruses140, 141, 142, cooling neutral atoms143, 144, 145 and fabricating nanoscale structures146. Hence, it is crucial to enhance the trapping forces for small particles. The main problem for trapping nanoparticles is that the gradient force decreases rapidly with decreasing particle size (the force is proportional to the third power of the particle radius). Small particles may easily escape the trapping potential well due to Brownian motion. Meanwhile, the diffraction limit of the trapping beam also hinders accurate trap confinement. Simply using higher numerical aperture lenses or increasing the laser power does not significantly improve the optical tweezer performance. In addition, high-power lasers cause instant damage to the particles due to thermal effects.
Fortunately, plasmon nanotweezers based on surface plasmon offer an alternative approach to scale the trapped objects down to the nanoscale. Surface plasmons are collective oscillations of charges at flat metal-dielectric interfaces147 (surface plasmon polaritons, SPPs) or bound electron plasmas on particles43 (localized surface plasmons, LSPs). The excited SPPs can be used to focus light energy far beyond the diffraction limit, which can greatly increase the precision of OM. Another merit of SPPs is that the evanescent field decays rapidly from the interface, inducing strong gradient forces and making the trapping more stable. Because evanescent wave trapping in the near-field is not subject to the diffraction limit and does not require a high numerical aperture lens, it is an attractive alternative method to manipulate nanoscale objects.
As the concept of using SPPs to enhance the trapping force with evanescent fields was introduced for optical trapping, various configurations have been proposed, such as channeled waveguide148, 149, external laser-illuminated metal tips and metallic layers with a subwavelength aperture150. These configurations can trap and move particles at the nanoscale. The local electric field is highly enhanced so that the induced optical forces are much larger than the forces from thermal fluctuations or gravity. For example, Zhang and colleagues151 used a metallic substrate coupled with a dielectric waveguide to confine a hybrid plasmonic mode between the waveguide and the substrate. The magnitude of optical force was greatly increased compared to the force when using a dielectric substrate. Subsequently, experimental realizations of SPP trapping were demonstrated using metal–dielectric interfaces, whereby surface plasmons are confined to subwavelength scales. Volpe et al.152 first observed and measured the plasmon radiation forces on dielectric spheres. They used a linearly polarized beam to impinge upon the metal-water interface through a prism to obtain surface plasmons. A polystyrene bead sample was placed between two separated cover slips. A photonic force microscope, which could obtain the optical force by analyzing the particle Brownian motion, was used to trap the probe particle and detect its position. To compare the forces in the surface plasmon resonant case and nonresonant case, the polarization of the incident electromagnetic wave can be changed to couple (transverse magnetic polarized) or decouple (transverse electric polarized) surface plasmons with the dielectric particle. In the experiment, the optical force magnitude at surface plasmon resonance was ~40 times larger than that off resonance. Wane et al.152, 153 placed gold particles very close (5 nm) to the gold film so that the particles could strongly couple with the gold film (Figure 5a). The momentum from the photons was effectively transferred to the nanoparticles and greatly reduced the illumination power. Exploiting surface plasmons not only improves the trapping well of optical tweezers but also makes parallel trapping of specific particles possible. Righini et al.154, 155 replaced the flat gold film with patterned gold disks in the Kretschmann configuration (Figure 5b), which could confine local fields to trap particles at desired positions. This configuration has potential applications in on-chip devices with non-focused beams and low laser power.
Recently, various new plasmonic structures, which are tunable, more efficient and generate less heat, have been proposed to dynamically trap objects156, 157, 158, 159, 160. Sainidou et al.157 theoretically designed open microcavities to trap and control nanoparticles by tuning the wavelength of applied light156. The position of nanoparticles inside the nanocavities can significantly vary the resonance modes of the plasmonic structure, producing a series of equilibrium positions for particular illumination wavelengths. Thus, the incident light can precisely manipulate the trapped nanoparticles. Similarly, by exploiting the strong effect of trapped particles on the local field, a self-induced back-action (SIBA) plasmonic trap was devised to dynamically and automatically control objects within the nanoaperture of a metallic film (Figure 6a). When the object moves away from the equilibrium point, a restoring force pulls it back because the movement of the object decreases the optical transmission through the aperture, leading to a backward force to compensate the decrement of photon momentum rate. Meanwhile, the SIBA approach greatly reduced the required optical intensity for trapping, improving the trapping efficiency. A subsequent experiment162 revealed the optomechanical nature of the SIBA effects to provide optimum conditions for SIBA-based tweezers. More recently, plasmonic structures have been integrated with electric and thermal fields to trap and lock nanoparticles with high resolution and lower input power (Figure 6b)161. In addition, exciting LSP is a good approach to trap nanoscale objects by coupling directly with the incident electromagnetic wave. A strong light spot can be generated between the gaps of metallic nanostructures, thus creating a giant optical trapping force. Various plasmonic dimers, such as dipole antennas, bowtie nanoantenna arrays and double-nanohole setups158, 160, 163, 164, have been widely used to control nanoparticles. LSP can also be applied to on-chip devices to simulatenously manipulate nanoscale beads or biological samples, such as living bacteria or cells, and may be extended to the molecule level to trap or sort single protein and DNA molecules.
Applications in biochemical manipulation
Currently, optical traps are one of the most preferred methods for manipulating objects in microscopic systems in the fields of physics, chemistry, biology and engineering. In particular, optical tweezers with gradient forces have proven to be an ideal tool in single-molecule biophysics. With the aid of modern positional analysis apparatuses, the motion and forces of a trapped biomolecule during biochemical interactions can be measured and studied. In the past two decades, a variety of biological mechanisms have been investigated using optical tweezers, such as the dynamics of motor molecules165, the motion of RNA polymerase during transcription (Figure 7a), the motion of ribosomes during translation170, protein folding171 and DNA-protein binding. Optical tweezers can also be used to trap and study single cells and organelles within cells172, 173, 174. However, fixed optical tweezers have some restrictions: they can only apply limited forces of 0.1–100 pN and can measure a range of motion of ~400 nm or less175. In this section, recent advances to overcome these restrictions and enable new manipulation features and biomedical applications are reviewed.
Recent studies of light–matter interactions have raised the upper limit of trapping forces by optimizing either the incident beam or the illuminated particles. Jannasch et al.176 demonstrated nanonewton optical trapping forces by applying an anti-reflection coating on high-refractive-index core–shell particles. These optimized particles can be used as handles to exert force on biomolecules. In the nanonewton range, processes such as the unfolding of proteins and nucleic acids and intercellular interactions can be studied using optical tweezers. To overcome the difficulty of trapping subwavelength scale objects, a set of near-field methods have been developed based on SPP and waveguide structures167. The trapping and transportation of particles as small as 75 nm, as well as λ-DNA molecules, were demonstrated using a slot waveguide (Figure 7b). Near-field trapping provides new abilities for manipulating small cells and biomolecules in space, which is a critical step in bioanalysis.
With the development of nanotechniques, the application of modern devices is not limited to OM. Micrototal analysis systems (lab-on-a-chip) can be easily combined with optical tweezers, making it possible to measure and explore the fluid–particle/particle–particle interactions and stress fields around biological cells. The integrated ‘lab-on-a-chip’ platform may enable imaging, sensing, bioanalysis and diagnosis on a single chip177, 178. On such a platform, the response of single cells to a range of gene manipulations or different biochemical environments may be recorded to study individual cellular functions179. Microfluidic systems consisting of a series of channels with diameters of ~100 μm are usually integrated on the platforms to assist the analysis. Therefore, OM over a relatively long distance can play an important role in these systems to controllably transport cells or biomolecules between areas. The distance of objects transported by fixed optical tweezers is greatly limited due to the short focal length of the lens, but this constraint can be broken by using ‘non-diffraction’ beams, such as Bessel21, 93, 180, 181, Mathieu182, 183 and Airy beams97, 184. Using this technique, an optical conveyor belt enabling bidirectional transportation was experimentally demonstrated. Again, particles optimized for optical pulling force can be used as handles attached to biomolecules. Integrating acousto-optic technology, which can generate arrays of such optical conveyors, will enable precise bidirectional transportation in three-dimensional space.
Near-field nanostructures can transport objects in a similar manner to ‘non-diffraction’ beams: the objects are trapped at the surface of the structure by gradient force and are continuously propelled by the scattering force. On the basis of current fabrication technology, these structures can be integrated with microfluidic systems on a ‘lab-on-a-chip’ platform to sort and fractionate biological molecules and cells185, 186, 187. A set of nanostructures has been developed to trap and transport biomolecules or cells, including waveguides and photonic crystals (Figure 7c). A structure with two micro-ring resonators with different resonant wavelengths integrated with a straight waveguide can be used to trap, transport and store particles188. By tuning the incident wavelength, particles can be transported and stored at different regions along the waveguide for a relatively long time. This device can be used to study cells’ responses to a series of environments in an orderly manner. In another resonator-waveguide system189, the optical pulling force on a micro-ring resonator was achieved using the net scattering momentum resulting from the mode conversion in the resonator. Combined with the lateral optical equilibrium effect, a bidirectional optical conveyor was proposed such that trapped objects and the resonator itself could be transported simultaneously. The ring resonator can be used as a carrier to transport biomolecules and cells in two directions. More recently, scientists have developed additional functions for optical tweezers, such as biosensing (Figure 7d). Photonic nanojets are able to confine subwavelength light fields and detect backscasttering signals from trapped nanoparticles at low optical power169.
In addition to force and displacement, torque generation is common in diverse cellular processes, such as DNA packing, transcription, replication and the functioning of rotary biomotors. An optical torque wrench190 can generate torque on trapped objects by transferring the SAM of the incident light. In the set-up, a birefringent object, such as a nanofabricated quartz cylinder, was used as a handle with one end attached to the molecule of interest. Torque along the long axis of the handle was generated by rotation of the polarization of the trapping laser191. The torque generated by the biomolecule can be transferred to the handle and measured by detecting the change in polarization between the light entering and leaving the handle. This method has been used to detect the torque of DNA during supercoiling191, and that of RNA polymerase during transcription192. In addition, light beams carry not only linear momentum but also AM, which can be applied to rotate particles in optical tweezers by transporting AM. By using a pre-designed optical set-up, left-handed or right-handed DNA/RNA-like molecules can be sorted if they are rotated in different directions, making it is possible to sort and manipulate individual DNA molecules (Figure 8a). Holographic optical tweezers can control the orientation of a cell at will and can achieve super-resolution using localization microscopy, yielding multiple perspectives of one sample with nanoscale localization precision(Figure 8b)194. The new developments will lead to another revolution in OM and create abundant opportunities in bioscience195.
Conclusions and future prospects
As a rapidly developing research field, there will be many possible trends and topics related to OM in future research. We have reviewed the new developments that have flourished in recent years. This area will continue to rapidly progress in the future.
On one hand, OM in inhomogeneous or complex backgrounds will attract increasing attention. Most manipulations are currently performed in water, air or another homogenous environment, such as a birefringent medium196. When the background is inhomogeneous, however, its scattering adds to that from the object and greatly contributes to the mechanical action on the body. For example, it has been shown that a simple dielectric interface can be used to achieve an optical tractor beam to transport oil droplets backward over long distances using only one beam23. In this situation, one of the most basic problems of OM is the optical force calculation, which stems from the momentum exchange between light and matter. For configurations with embedding backgrounds that are more complex than a uniform medium bounded only by a planar interface, interesting optical trapping and manipulation techniques, together with sophisticated calculations of the optical force in such situations, may attract growing interest.
On the other hand, the focus will be on the manipulation, sorting and separation of nanoscale objects with dimensions of tens of nanometers. The gradient force Fg of optical tweezers rapidly scales down as the linear dimensions r of the object decrease, namely, Fg~r3. Therefore, objects with a typical size of tens of nanometers are challenging to trap and manipulate through gradient forces, as these forces are miniscule, and their potential is overcome by convection currents in the environment or by Brownian motion of such tiny bodies. Trapping and spatially controlling such objects in an accurate way at the nanometer scale is a key issue to building new functional nano-devices.
With the recent abundant advances, we anticipate the following research trends in OM. First, more novel beams will emerge as tractor beams by carefully constructing the properties of the electromagnetic field. The limitations of the current tractor beams will be overcome by increasingly powerful modern optics. Meanwhile, proper background materials, such as metamaterials, will also play an important role in optical trapping. New optical phenomena may help to reveal light–matter interactions. Second, ultra-accurate manipulation requires finer structures, even down to the subnanoscale, at which quantum tunneling, nonlocal and nonlinear effects should be taken into account. Furthermore, the increasing miniaturization of nano-tweezers makes it easier to implement them into integrated analytical platforms43. Multi-function sensors with high spatial resolution down to the microscale may be used to monitor various physical parameters, such as electric fields, magnetic fields, temperature, vibration and even radiation levels, by detecting the tweezered particles or the transmitted signal in a photonic crystal fiber197. With the development of nanotechnology, the size of these sensors can be soon reduced to nanometers. Meanwhile, trapping scale will be further narrowed to <10 nm when optical tweezers are integrated with novel techniques or configurations. For example, a sub-10 nm parallel electronic trap fabricated by atomic layer lithography was able to rapidly electronically trap nanoparticles between long electrodes with ultralow bias voltages198. A promising next generation of nanophotonic traps using silicon nitride waveguides can outperform conventional table-top laser trapping in most respect, such as subnanometer manipulation resolution, the volume and stiffness of trapping and the maneuverability of devices199. OM may progress towards becoming multifunctional, highly compact and ultra-accurate, with diverse promising applications in biosciences, chemistry and engineering.
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CWQ acknowledges the financial support from the National University of Singapore (no. R-263-000-678-133). MN-V is supported by the Spanish MINECO grants FIS2012-36113-C03-03, FIS2014-55563-REDC and FIS2015-69295-C3-1-P. DLG acknowledges financial support from the National Natural Science Foundation of China (no. 11504252), the Natural Science Foundation for the Youth of Jiangsu Province (no. BK20150306), and the Natural Science Foundation for Colleges and Universities in Jiangsu Province of China (no. 15KJB140008).
The authors declare no conflict of interest.
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Gao, D., Ding, W., Nieto-Vesperinas, M. et al. Optical manipulation from the microscale to the nanoscale: fundamentals, advances and prospects. Light Sci Appl 6, e17039 (2017). https://doi.org/10.1038/lsa.2017.39
- biochemical manipulation
- optical force
- optical tweezer
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