Subscribe to Journal
Get full journal access for 1 year
We are sorry, but there is no personal subscription option available for your country.
Rent or Buy article
Get time limited or full article access on ReadCube.
All prices are NET prices.
Thomas ED, Storb R, Clift RA, Fefer A, Johnson FL, Neiman PE et al. Bone marrow transplantation. N Engl J Med 1975; 292: 832–843.
Apperley JF, Mauro FR, Goldman JM, Gregory W, Arthur CK, Hows J et al. Bone marrow transplantation for chronic myeloid leukemia in first chronic phase: importance of a graft-versus-leukemia effect. Br J Haematol 1988; 69: 239–245.
Yong AS, Goldman JM . Relapse of chronic myeloid leukaemia 14 years after allogeneic bone marrow transplantation. Bone Marrow Transplant 1999; 23: 827–828.
Frassoni F, Labopin M, Gluckman E, Prentice HG, Gahrton G, Mandelli F et al. Are patients with acute leukaemia, alive and well 2 years post bone marrow transplantation cured? A European survey. Acute Leukaemia Working Party of the European Group for Bone Marrow Transplantation (EBMT). Leukemia 1994; 8: 924–928.
Kolb HJ, Gunther W, Schumm M, Holler E, Wilmanns W, Thierfelder S et al. Adoptive immunotherapy in canine chimeras. Transplantation 1997; 63: 430–436.
Kolb HJ, Mittermuller J, Clemm C, Holler E, Ledderose G, Brehm G et al. Donor leukocyte transfusions for treatment of recurrent chronic myelogenous leukemia in marrow transplant patients. Blood 1990; 76: 2462–2465.
Kolb HJ, Schattenberg A, Goldman JM, Hertenstein B, Jacobsen N, Arcese W et al. Graft-versus-leukemia effect of donor lymphocyte transfusions in marrow grafted patients 397. Blood 1995; 86: 2041–2050.
Chen X, Woiciechowsky A, Raffegerst S, Schendel D, Kolb HJ, Roskrow M . Impaired expression of the CD3-zeta chain in peripheral blood T cells of patients with chronic myeloid leukaemia results in an increased susceptibility to apoptosis. Br J Haematol 2000; 111: 817–825.
Chen X, Regn S, Raffegerst S, Kolb HJ, Roskrow M . Interferon alpha in combination with GM-CSF induces the differentiation of leukaemic antigen-presenting cells that have the capacity to stimulate a specific anti-leukaemic cytotoxic T-cell response from patients with chronic myeloid leukaemia. Br J Haematol 2000; 111: 596–607.
Essers MA, Offner S, Blanco-Bose WE, Waibler Z, Kalinke U, Duchosal MA et al. IFNalpha activates dormant haematopoietic stem cells in vivo. Nature 2009; 458: 904–908.
CF and AM received grant support from the German Research Foundation (DFG TransRegio SFB 36, B8) and Integrated Research and Treatment Center Transplantation (IFB-Tx). The symposium and publication of this supplement were sponsored by the Division of Hematology / Oncology at the Warren Alpert Medical School of Brown University and NIH Center of Biomedical Research Excellence (COBRE) for Stem Cells Biology at Rhode Island Hospital.
H-JK and SH have received lecture fees from Neovii Fresenius Biotech EBMT and TEVA education. RB declares no conflict of interest.
About this article
Cite this article
Kolb, HJ., Schmetzer, H., Schmid, C. et al. Mechanisms of graft-versus-leukemia effects after allogeneic stem cell transplantation: effects on the leukemia stem cell?. Leukemia Suppl 3, S16–S17 (2014). https://doi.org/10.1038/leusup.2014.9
- allogeneic stem cell transplantation with T cell depletion
- Transfusion of Donor Lymphocytes