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Reconsidering marrow stem cell cycle status: insights into an actively cycling hematopoietic stem cell population

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  1. 1

    Goodell MA, Brose K, Paradis G, Conner AS, Mulligan RC . Isolation and functional properties of murine hematopoietic stem cells that are replicating in vivo. J Exp Med 1996; 183: 1797–1806.

    CAS  Article  Google Scholar 

  2. 2

    Morrison SJ, Weissman IL . The long-term repopulating subset of hematopoietic stem cells is deterministic and isolatable by phenotype. Immunity 1994; 1: 661–673.

    CAS  Article  Google Scholar 

  3. 3

    Osawa M, Hanada K, Hamada H, Nakauchi H . Long-term lymphohematopoietic reconstitution by a single CD34-low/negative hematopoietic stem cell. Science 1996; 273: 242–252.

    CAS  Article  Google Scholar 

  4. 4

    Christensen JL, Weissman IL . Flk-2 is a marker in hematopoietic stem cell differentiation: a simple method to isolate long-term stem cells. Proc Natl Acad Sci USA 2001; 98: 14541–14546.

    CAS  Article  Google Scholar 

  5. 5

    Oguro H, Ding L, Morrison SJ . SLAM family markers resolve functionally distinct subpopulations of hematopoietic stem cells and multipotent progenitors. Cell Stem Cell 2013; 13: 102–116.

    CAS  Article  Google Scholar 

  6. 6

    Fleming WH, Alpern EJ, Uchida N, Ikuta K, Sprangrude GJ, Weissman IL et al. Functional heterogeneity is associated with the cell cycle status of murine hematopoietic stem cells. J Cell Biol 1993; 122: 897–902.

    CAS  Article  Google Scholar 

  7. 7

    Passegué E, Wagers AJ, Giuriato S, Anderson WC, Weissman IL . Global analysis of proliferation and cell cycle gene expression in the regulation of hematopoietic stem and progenitor cell fates. J Exp Med 2005; 202: 1599–1611.

    Article  Google Scholar 

  8. 8

    Orschell-Traycoff CM, Hiatt K, Dagher RN, Rice S, Yoder MC, Srour EF et al. Homing and engraftment potential of Sca-1+lin cells fractionated on the basis of adhesion molecule expression and position in cell cycle. Blood 2000; 96: 1380–1387.

    CAS  Article  Google Scholar 

  9. 9

    Goldberg LR, Dooner MS, Johnson K, Papa E, Pereira M, Del Tatto M et al. The murine long-term multi-lineage renewal marrow stem cell is a cycling cell. Leukemia 2014; 28: 813–822.

    CAS  Article  Google Scholar 

  10. 10

    Lambert J-F, Liu M, Colvin GA, Dooner M, McAuliffe CI, Becker PS et al. Marrow stem cells shift gene expression and engraftment phenotype with cell cycle transit. J Exp Med 2003; 197: 1563–1572.

    CAS  Article  Google Scholar 

  11. 11

    Colvin GA, Dooner MS, Dooner G, Sanchez-Guijo FM, Demers DA, Abedi M et al. Stem cell continuum: directed differentiation hotspots. Exp Hematol 2007; 35: 96–107.

    CAS  Article  Google Scholar 

  12. 12

    Cerny J, Dooner M, McAuliffe C, Habibian H, Stencil K, Berrios V et al. Homing of purified murine lymphohematopoietic stem cells: a cytokine-induced defect. J Hematother Stem Cell Res 2002; 11: 913–922.

    CAS  Article  Google Scholar 

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LG received grant support from the National Institute of General Medical Sciences (NIGMS) of the National Institutes of Health through Grant Number P20GM103468 and from the Herbert W. Savit Research Fellowship. The symposium and publication of this supplement were sponsored by the Division of Hematology/Oncology at the Warren Alpert Medical School of Brown University and NIH Center of Biomedical Research Excellence (COBRE) for Stem Cells Biology at Rhode Island Hospital.

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Correspondence to L R Goldberg.

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Goldberg, L. Reconsidering marrow stem cell cycle status: insights into an actively cycling hematopoietic stem cell population. Leukemia Suppl 3, S12–S13 (2014).

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  • highly purified stem cells
  • quiescence
  • cycling stem cells
  • stem cells heterogeneity
  • stem cell markers


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