Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Novel view on hematopoietic stem cell mobilization and homing

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Figure 1

References

  1. 1

    Lévesque JP, Helwani FM, Winkler IG . The endosteal 'osteoblastic' niche and its role in hematopoietic stem cell homing and mobilization. Leukemia 2010; 24: 1979–1992.

    Article  Google Scholar 

  2. 2

    Bonig H, Papayannopoulou T . Hematopoietic stem cell mobilization: updated conceptual renditions. Leukemia 2013; 27: 24–31.

    CAS  Article  Google Scholar 

  3. 3

    Lapidot T, Kollet O . The brain-bone-blood triad: traffic lights for stem-cell homing and mobilization. Hematology Am Soc Hematol Educ Program 2010; 2010: 1–6.

    Article  Google Scholar 

  4. 4

    Ratajczak MZ, Kim CH, Wojakowski W, Janowska-Wieczorek A, Kucia M, Ratajczak J et al. Innate immunity as orchestrator of stem cell mobilization. Leukemia 2010; 24: 1667–1675.

    CAS  Article  Google Scholar 

  5. 5

    Ratajczak MZ, Kim CH, Abdel-Latif A, Schneider G, Kucia M, Morris AJ et al. A novel perspective on stem cell homing and mobilization: review on bioactive lipids as potent chemoattractants and cationic peptides as underappreciated modulators of responsiveness to SDF-1 gradients. Leukemia 2012; 26: 63–72.

    CAS  Article  Google Scholar 

  6. 6

    Ratajczak MZ, Kim CH, Janowska-Wieczorek A, Ratajczak J . The expanding family of bone marrow homing factors for hematopoietic stem cells: stromal derived factor 1 is not the only player in the game. The ScientificWorld Journal 2012; 2012: 758512.

    Article  Google Scholar 

  7. 7

    Wu W, Kim CH, Liu R, Kucia M, Marlicz W, Greco N et al. The bone marrow-expressed antimicrobial cationic peptide LL-37 enhances the responsiveness of hematopoietic stem progenitor cells to an SDF-1 gradient and accelerates their engraftment after transplantation. Leukemia 2012; 26: 736–745.

    CAS  Article  Google Scholar 

  8. 8

    Hoggatt J, Pelus LM . Eicosanoid regulation of hematopoiesis and hematopoietic stem and progenitor trafficking. Leukemia 2010; 24: 1993–2002.

    CAS  Article  Google Scholar 

  9. 9

    Ma Q, Jones D, Springer TA . The chemokine receptor CXCR4 is required for the retention of B lineage and granulocytic precursors within the bone marrow microenvironment. Immunity 1999; 10: 463–471.

    CAS  Article  Google Scholar 

  10. 10

    Christopherson KW II, Hangoc G, Mantel CR, Broxmeyer HE . ‘Modulation of hematopoietic stem cell homing and engraftment by CD26’. Science 2004; 305: 1000–1003.

    CAS  Article  Google Scholar 

  11. 11

    Borkowska S, Suszynska M, Mierzejewska K, Ismail A, Budkowska M, Salata D et al. Novel evidence that crosstalk between the complement, coagulation, and fibrinolysis proteolytic cascades is involved in mobilization of hematopoietic stem/progenitor cells (HSPCs). Leukemia 2014; 28: 2148–2154.

    CAS  Article  Google Scholar 

  12. 12

    Wolk R, Gami AS, Garcia-Touchard A, Somers VK . Sleep and cardiovascular disease. Curr Probl Cardiol 2005; 30: 625–662.

    Article  Google Scholar 

  13. 13

    Katayama Y, Battista M, Kao WM, Hidalgo A, Peired AJ, Thomas SA et al. Signals from the sympathetic nervous system regulate hematopoietic stem cell egress from bone marrow. Cell 2006; 124: 407–421.

    CAS  Article  Google Scholar 

  14. 14

    Golan K, Vagima Y, Ludin A, Itkin T, Cohen-Gur S, Kalinkovich A et al. S1P promotes murine progenitor cell egress and mobilization via S1P1-mediated ROS signaling and SDF-1 release. Blood 2012; 119: 2478–2488.

    CAS  Article  Google Scholar 

  15. 15

    Juarez JG, Harun N, Thien M, Welschinger R, Baraz R, Pena AD et al. Sphingosine-1-phosphate facilitates trafficking of hematopoietic stem cells and their mobilization by CXCR4 antagonists in mice. Blood 2012; 119: 707–716.

    CAS  Article  Google Scholar 

Download references

Acknowledgements

MR received grant support from NIH Research Project Grant Program (R01 – DK074720 and HL112788). The symposium and publication of this supplement were sponsored by the Division of Hematology/Oncology at the Warren Alpert Medical School of Brown University and NIH Center of Biomedical Research Excellence (COBRE) for Stem Cells Biology at Rhode Island Hospital.

Author information

Affiliations

Authors

Corresponding author

Correspondence to M Z Ratajczak.

Ethics declarations

Competing interests

The author declares no conflict of interest.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Ratajczak, M. Novel view on hematopoietic stem cell mobilization and homing. Leukemia Suppl 3, S19–S20 (2014). https://doi.org/10.1038/leusup.2014.11

Download citation

Keywords

  • sphingosine-1 phosphate
  • ceramide 1-phosphate
  • SDF-1 chemotactic gradient
  • complement cascade
  • coagulation cascade
  • fibrynolytic cascade
  • stem cell mobilization
  • stem cell homing

Search

Quick links