Abstract
The purpose of evaluating prognostic factors in acute lymphoblastic leukemia is, first, to stratify patients into adverse- or good-risk groups, second, to determine different treatment options accordingly and, third, to evaluate their potential outcome. Prognostic factors are particularly relevant for disease-free survival and overall survival.
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References
Gunz F, Baikie AG . Leukemia, 3rd edn. Nankodo, Ltd: Tokyo, 1974.
Hoelzer D, Thiel E, Loffler H, Bodenstein H, Plaumann L, Buchner T et al. Intensified therapy in acute lymphoblastic and acute undifferentiated leukemia in adults. Blood 1984; 64: 38–47.
Hoelzer D, Thiel E, Loffler H, Ganser A, Heimpel H, Buchner T et al. Risk groups in adult acute lymphoblastic leukemia. Haematol Blood Transfus 1987; 30: 104–110.
Gaynor J, Chapman D, Little C, McKenzie S, Miller W, Andreeff M et al. A cause-specific hazard rate analysis of prognostic factors among 199 adults with acute lymphoblastic leukemia: the Memorial Hospital experience since 1969. J Clin Oncol 1988; 6: 1014–1030.
Kantarjian HM, O’Brien S, Smith TL, Cortes J, Giles FJ, Beran M et al. Results of treatment with hyper-CVAD, a dose-intensive regimen, in adult acute lymphocytic leukemia. J Clin Oncol 2000; 18: 547–561.
Larson RA, Dodge RK, Burns CP, Lee EJ, Stone RM, Schulman P et al. A five-drug remission induction regimen with intensive consolidation for adults with acute lymphoblastic leukemia: cancer and leukemia group B study 8811. Blood 1995; 85: 2025–2037.
Bassan R, Hoelzer D . Modern therapy of acute lymphoblastic leukemia. J Clin Oncol 2011; 29: 532–543.
Gokbuget N, Hoelzer D, Arnold R, Bohme A, Bartram CR, Freund M et al. Treatment of adult ALL according to protocols of the German Multicenter Study Group for Adult ALL (GMALL). Hematol Oncol Clin North Am 2000; 14: 1307–1325, ix.
Bassan R, Intermesoli T, Oldani E . Prognostic factors and risk adapted therapy. In: Gökbuget N, Bassan R, Dombret H et al. (eds) Recommendations of the European Working Group for Adult ALL, 1st edn. UNI-MED Verlag AG: Bremen, 2011.
Acknowledgements
NG has also received grant support from GlaxoSmithKline, Mundipharma, Genzyme Corporation, EUSA Pharma, Micromet Inc., Medac Inc. and the Jose Carreras Foundation.
This article was published as part of a supplement that was supported by Novartis, MSD Italia, Roche, Celgene, GlaxoSmithKline, Sanofi, Gilead, Adienne, Italfarmaco, Pierre Fabre Pharmaceuticals with an unrestricted educational contribution to AREO—Associazione Ricerche Emato-Oncologiche (Genoa) and AMS—Associazione Malattie del Sangue (Milan) for the purpose of advancing research in acute and chronic leukemia.
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NG has received consulting fees from Micromet Inc., Gilead, ERYtech Pharma and Mundipharma, and received lecture fees from Medac Inc., GlaxoSmithKline and Mundipharma. DH declares no conflict of interest.
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Hoelzer, D., Gökbuget, N. Change in prognostic factors. Leukemia Suppl 1 (Suppl 2), S1–S2 (2012). https://doi.org/10.1038/leusup.2012.4
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DOI: https://doi.org/10.1038/leusup.2012.4