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Epigenetic targeting of Notch1-driven transcription using the HDACi panobinostat is a potential therapy against T-cell acute lymphoblastic leukemia

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Acknowledgements

The work was funded by the Australian National Health and Medical Research Council. MW was supported by a fellowship from the Deutsche Forschungsgemeinschaft and funding from the NHMRC. SJV was funded by a Rubicon fellowship from the Netherlands Organization for Scientific Research. EDH was supported by a fellowship from the National Health and Medical Research Council of Australia. RWJ was supported by a National Health and Medical Research Council (NHMRC) Senior Principal Research Fellowship, project and program grants from the NHMRC, the Cancer Council Victoria and the Victorian Cancer Agency. EDH would like to thank Sarah Russell for mentorship through the project.

Author contributions

MW, SJV, SH, EDH and RWJ designed the experiments. MW, SJV, IYK, BPM, KMR and EDH performed the experiments. MW, SJV, IYK, BPM, KMR and EDH analyzed the data. MW, SJV, EDH and RWJ wrote the manuscript.

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Correspondence to E D Hawkins or R W Johnstone.

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Competing interests

The Johnstone laboratory receives research funding from Novartis for studies involving panobinostat.

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Supplementary Information accompanies this paper on the Leukemia website

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Waibel, M., Vervoort, S., Kong, I. et al. Epigenetic targeting of Notch1-driven transcription using the HDACi panobinostat is a potential therapy against T-cell acute lymphoblastic leukemia. Leukemia 32, 237–241 (2018). https://doi.org/10.1038/leu.2017.282

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