This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Facile repurposing of peptide–MHC-restricted antibodies for cancer immunotherapy
Nature Biotechnology Open Access 02 January 2023
-
Tumor-promoting myeloid cells in the pathogenesis of human oncoviruses: potential targets for immunotherapy
Cancer Cell International Open Access 27 October 2022
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Rent or buy this article
Prices vary by article type
from$1.95
to$39.95
Prices may be subject to local taxes which are calculated during checkout
References
Chang AY, Dao T, Gejman RS, Jarvis CA, Scott A, Dubrovsky L et al. A therapeutic T cell receptor mimic antibody targets tumor-associated PRAME peptide/HLA-I anigens. JCI 2017; 127: 2705–2718.
Dao T, Yan S, Veomett N, Pankov D, Zhou L, Korontsvit T et al. Targeting the intracellular WT1 oncogene product with a therapeutic human antibody. Sci Transl Med 2013; 5: 176ra33.
Veomett N, Dao T, Liu H, Xiang J, Pankov D, Dubrovsky L et al. Therapeutic efficacy of an Fc-enhanced TCR-like antibody to the intracellular WT1 oncoprotein. Clin Cancer Res 2014; 20: 4036–4046.
Dubrovsky L, Pankov D, Brea EJ, Dao T, Scott A, Yan S et al. A TCR-mimic antibody to WT1 bypasses tyrosine kinase inhibitor resistance in human BCR-ABL+ leukemias. Blood 2014; 123: 3296–3304.
Verma B, Jain R, Caseltine S, Rennels A, Bhattacharya R, Markiewski MM et al. TCR mimic monoclonal antibodies induce apoptosis of tumor cells via immune effector-independent mechanisms. J Immunol 2011; 186: 3265–3276.
Petrova PS, Viller NN, Wong M, Pang X, Lin GH, Dodge K et al. TTI-621 (SIRPalphaFc): a CD47-blocking innate immune checkpoint inhibitor with broad anti-tumor activity and minimal erythrocyte binding. Clin Cancer Res 2016; 23: 1068–1079.
van den Berg TK, van Bruggen R . Loss of CD47 makes dendritic cells see red. Immunity 2015; 43: 622–624.
Weiskopf K, Ring AM, Ho CC, Volkmer JP, Levin AM, Volkmer AK et al. Engineered SIRPalpha variants as immunotherapeutic adjuvants to anticancer antibodies. Science 2013; 341: 88–91.
Parker BS, Rautela J, Hertzog PJ . Antitumour actions of interferons: implications for cancer therapy. Nat Rev Cancer 2016; 16: 131–144.
Liu X, Pu Y, Cron K, Deng L, Kline J, Frazier WA et al. CD47 blockade triggers T cell-mediated destruction of immunogenic tumors. Nat Med 2015; 21: 1209–1215.
Liu Y, Buhring HJ, Zen K, Burst SL, Schnell FJ, Williams IR et al. Signal regulatory protein (SIRPalpha), a cellular ligand for CD47, regulates neutrophil transmigration. J Biol Chem 2002; 277: 10028–10036.
Bruhns P . Properties of mouse and human IgG receptors and their contribution to disease models. Blood 2012; 119: 5640–5649.
Shultz LD, Lyons BL, Burzenski LM, Gott B, Chen X, Chaleff S et al. Human lymphoid and myeloid cell development in NOD/LtSz-scid IL2R gamma null mice engrafted with mobilized human hemopoietic stem cells. J Immunol 2005; 174: 6477–6489.
Darwich L, Coma G, Pena R, Bellido R, Blanco EJ, Este JA et al. Secretion of interferon-gamma by human macrophages demonstrated at the single-cell level after costimulation with interleukin (IL)-12 plus IL-18. Immunology 2009; 126: 386–393.
Tanaka S, Saito Y, Kunisawa J, Kurashima Y, Wake T, Suzuki N et al. Development of mature and functional human myeloid subsets in hematopoietic stem cell-engrafted NOD/SCID/IL2rgammaKO mice. J Immunol 2012; 188: 6145–6155.
Acknowledgements
Author contributions
MDM—experimental design, animal experiments, drafting of manuscript; JTS—experimental design, in vitro experiments, drafting of manuscript; AYC—Pr20 characterization, biochemistry and immunology, drafting of manuscript; KST—statistical design and analysis; CL—creation and manufacturing of ESK and Pr20; KCG—experimental design, analysis, drafting of manuscript; DAS—experimental design, analysis, drafting of manuscript.
Author information
Authors and Affiliations
Corresponding authors
Ethics declarations
Competing interests
CL: equity in Eureka; KCG: equity in Alexo Therapeutics; DAS: consultant to Eureka. The remaining authors declare no conflict of interest.
Additional information
Supplementary Information accompanies this paper on the Leukemia website
Supplementary information
Rights and permissions
About this article
Cite this article
Mathias, M., Sockolosky, J., Chang, A. et al. CD47 blockade enhances therapeutic activity of TCR mimic antibodies to ultra-low density cancer epitopes. Leukemia 31, 2254–2257 (2017). https://doi.org/10.1038/leu.2017.223
Published:
Issue Date:
DOI: https://doi.org/10.1038/leu.2017.223
This article is cited by
-
Facile repurposing of peptide–MHC-restricted antibodies for cancer immunotherapy
Nature Biotechnology (2023)
-
Tumor-promoting myeloid cells in the pathogenesis of human oncoviruses: potential targets for immunotherapy
Cancer Cell International (2022)