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Chang AY, Dao T, Gejman RS, Jarvis CA, Scott A, Dubrovsky L et al. A therapeutic T cell receptor mimic antibody targets tumor-associated PRAME peptide/HLA-I anigens. JCI 2017; 127: 2705–2718.
Dao T, Yan S, Veomett N, Pankov D, Zhou L, Korontsvit T et al. Targeting the intracellular WT1 oncogene product with a therapeutic human antibody. Sci Transl Med 2013; 5: 176ra33.
Veomett N, Dao T, Liu H, Xiang J, Pankov D, Dubrovsky L et al. Therapeutic efficacy of an Fc-enhanced TCR-like antibody to the intracellular WT1 oncoprotein. Clin Cancer Res 2014; 20: 4036–4046.
Dubrovsky L, Pankov D, Brea EJ, Dao T, Scott A, Yan S et al. A TCR-mimic antibody to WT1 bypasses tyrosine kinase inhibitor resistance in human BCR-ABL+ leukemias. Blood 2014; 123: 3296–3304.
Verma B, Jain R, Caseltine S, Rennels A, Bhattacharya R, Markiewski MM et al. TCR mimic monoclonal antibodies induce apoptosis of tumor cells via immune effector-independent mechanisms. J Immunol 2011; 186: 3265–3276.
Petrova PS, Viller NN, Wong M, Pang X, Lin GH, Dodge K et al. TTI-621 (SIRPalphaFc): a CD47-blocking innate immune checkpoint inhibitor with broad anti-tumor activity and minimal erythrocyte binding. Clin Cancer Res 2016; 23: 1068–1079.
van den Berg TK, van Bruggen R . Loss of CD47 makes dendritic cells see red. Immunity 2015; 43: 622–624.
Weiskopf K, Ring AM, Ho CC, Volkmer JP, Levin AM, Volkmer AK et al. Engineered SIRPalpha variants as immunotherapeutic adjuvants to anticancer antibodies. Science 2013; 341: 88–91.
Parker BS, Rautela J, Hertzog PJ . Antitumour actions of interferons: implications for cancer therapy. Nat Rev Cancer 2016; 16: 131–144.
Liu X, Pu Y, Cron K, Deng L, Kline J, Frazier WA et al. CD47 blockade triggers T cell-mediated destruction of immunogenic tumors. Nat Med 2015; 21: 1209–1215.
Liu Y, Buhring HJ, Zen K, Burst SL, Schnell FJ, Williams IR et al. Signal regulatory protein (SIRPalpha), a cellular ligand for CD47, regulates neutrophil transmigration. J Biol Chem 2002; 277: 10028–10036.
Bruhns P . Properties of mouse and human IgG receptors and their contribution to disease models. Blood 2012; 119: 5640–5649.
Shultz LD, Lyons BL, Burzenski LM, Gott B, Chen X, Chaleff S et al. Human lymphoid and myeloid cell development in NOD/LtSz-scid IL2R gamma null mice engrafted with mobilized human hemopoietic stem cells. J Immunol 2005; 174: 6477–6489.
Darwich L, Coma G, Pena R, Bellido R, Blanco EJ, Este JA et al. Secretion of interferon-gamma by human macrophages demonstrated at the single-cell level after costimulation with interleukin (IL)-12 plus IL-18. Immunology 2009; 126: 386–393.
Tanaka S, Saito Y, Kunisawa J, Kurashima Y, Wake T, Suzuki N et al. Development of mature and functional human myeloid subsets in hematopoietic stem cell-engrafted NOD/SCID/IL2rgammaKO mice. J Immunol 2012; 188: 6145–6155.
MDM—experimental design, animal experiments, drafting of manuscript; JTS—experimental design, in vitro experiments, drafting of manuscript; AYC—Pr20 characterization, biochemistry and immunology, drafting of manuscript; KST—statistical design and analysis; CL—creation and manufacturing of ESK and Pr20; KCG—experimental design, analysis, drafting of manuscript; DAS—experimental design, analysis, drafting of manuscript.
CL: equity in Eureka; KCG: equity in Alexo Therapeutics; DAS: consultant to Eureka. The remaining authors declare no conflict of interest.
Supplementary Information accompanies this paper on the Leukemia website
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Mathias, M., Sockolosky, J., Chang, A. et al. CD47 blockade enhances therapeutic activity of TCR mimic antibodies to ultra-low density cancer epitopes. Leukemia 31, 2254–2257 (2017). https://doi.org/10.1038/leu.2017.223